Chen Hui Juan, Ke Jun, Qiu Jie, Xu Qiang, Zhong Yuan, Lu Guang Ming, Wu Yanglei, Qi Rongfeng, Chen Feng
Department of Radiology, Hainan General Hospital (Hainan Affiliated Hospital of Hainan Medical University), Haikou, China.
Department of Medical Imaging, Jinling Hospital, Medical School, Nanjing University, Nanjing, China.
Ther Adv Psychopharmacol. 2023 Jun 17;13:20451253231175302. doi: 10.1177/20451253231175302. eCollection 2023.
Altered resting-state functional connectivity has been found in patients with post-traumatic stress disorder (PTSD). However, the alteration of resting-state functional connectivity at whole-brain level in typhoon-traumatized individuals with PTSD remains largely unknown.
To investigate changes in whole-brain resting-state functional connectivity and brain network topology in typhoon-traumatized subjects with and without PTSD.
Cross-sectional study.
Twenty-seven patients with typhoon-related PTSD, 33 trauma-exposed controls (TEC), and 30 healthy controls (HC) underwent resting-state functional MRI scanning. The whole brain resting-state functional connectivity network was constructed based on the automated anatomical labeling atlas. The graph theory method was used to analyze the topological properties of the large-scale resting-state functional connectivity network. Whole-brain resting-state functional connectivity and the topological network property were compared by analyzing the variance.
There was no significant difference in the area under the curve of γ, λ, σ, global efficiency, and local efficiency among the three groups. The PTSD group showed increased dorsal cingulate cortex (dACC) resting-state functional connectivity with the postcentral gyrus (PoCG) and paracentral lobe and increased nodal betweenness centrality in the precuneus relative to both control groups. Compared with the PTSD and HC groups, the TEC group showed increased resting-state functional connectivity between the hippocampus and PoCG and increased connectivity strength in the putamen. In addition, compared with the HC group, both the PTSD and TEC groups showed increased connectivity strength and nodal efficiency in the insula.
Aberrant resting-state functional connectivity and topology were found in all trauma-exposed individuals. These findings broaden our knowledge of the neuropathological mechanisms of PTSD.
创伤后应激障碍（PTSD）患者存在静息态功能连接改变。然而，台风创伤后患有PTSD的个体全脑水平静息态功能连接的改变仍不清楚。
研究有和无PTSD的台风创伤个体全脑静息态功能连接及脑网络拓扑结构的变化。
横断面研究。
27例与台风相关的PTSD患者、33例创伤暴露对照者（TEC）和30例健康对照者（HC）接受静息态功能磁共振成像扫描。基于自动解剖标记图谱构建全脑静息态功能连接网络。采用图论方法分析大规模静息态功能连接网络的拓扑特性。通过方差分析比较全脑静息态功能连接和拓扑网络特性。
三组之间γ、λ、σ曲线下面积、全局效率和局部效率无显著差异。与两个对照组相比，PTSD组背侧扣带回皮质（dACC）与中央后回（PoCG）和中央旁小叶的静息态功能连接增加，楔前叶节点中介中心性增加。与PTSD组和HC组相比，TEC组海马与PoCG之间的静息态功能连接增加，壳核连接强度增加。此外，与HC组相比，PTSD组和TEC组脑岛的连接强度和节点效率均增加。
在所有创伤暴露个体中均发现异常的静息态功能连接和拓扑结构。这些发现拓宽了我们对PTSD神经病理机制的认识。
