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微创活体肝移植切除术的全球推广:障碍有哪些?

Global dissemination of minimally invasive living donor hepatectomy: What are the barriers?

作者信息

Kakos Christos Dimitrios, Papanikolaou Angelos, Ziogas Ioannis A, Tsoulfas Georgios

机构信息

Surgery Working Group, Society of Junior Doctors, Athens 15123, Greece.

Department of Transplant Surgery, Aristotle University of Thessaloniki, School of Medicine, Thessaloniki 54622, Greece.

出版信息

World J Gastrointest Surg. 2023 May 27;15(5):776-787. doi: 10.4240/wjgs.v15.i5.776.

DOI:10.4240/wjgs.v15.i5.776
PMID:37342850
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10277954/
Abstract

Minimally invasive donor hepatectomy (MIDH) is a relatively novel procedure that can potentially increase donor safety and contribute to faster rehabilitation of donors. After an initial period in which donor safety was not effectively validated, MIDH currently seems to provide improved results, provided that it is conducted by experienced surgeons. Appropriate selection criteria are crucial to achieve better outcomes in terms of complications, blood loss, operative time, and hospital stay. Beyond a pure laparoscopic technique, various approaches have been recommended such as hand-assisted, laparoscopic-assisted, and robotic donation. The latter has shown equal outcomes compared to open and laparoscopic approaches. A steep learning curve seems to exist in MIDH, mainly due to the fragility of the liver parenchyma and the experience needed for adequate control of bleeding. This review investigated the challenges and the opportunities of MIDH and the barriers to its global dissemination. Surgeons need expertise in liver transplantation, hepatobiliary surgery, and minimally invasive techniques to perform MIDH. Barriers can be categorized into surgeon-related, institutional-related, and accessibility. More robust data and the creation of international registries are needed for further evaluation of the technique and the acceptance from more centers worldwide.

摘要

微创供体肝切除术(MIDH)是一种相对新颖的手术方法,它有可能提高供体安全性,并有助于供体更快康复。在最初一段时间内,供体安全性未得到有效验证,目前MIDH似乎能取得更好的效果,前提是由经验丰富的外科医生进行操作。合适的选择标准对于在并发症、失血、手术时间和住院时间方面取得更好的结果至关重要。除了单纯的腹腔镜技术外,还推荐了多种方法,如手辅助、腹腔镜辅助和机器人供肝。与开放和腹腔镜方法相比,后者已显示出相同的效果。MIDH似乎存在陡峭的学习曲线,主要是由于肝实质的脆弱性以及充分控制出血所需的经验。本综述探讨了MIDH的挑战与机遇及其全球推广的障碍。外科医生需要具备肝移植、肝胆外科和微创技术方面的专业知识才能进行MIDH。障碍可分为与外科医生相关、与机构相关和可及性方面的障碍。需要更有力的数据并建立国际登记处,以便对该技术进行进一步评估,并获得全球更多中心的认可。

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本文引用的文献

1
Comparing purely laparoscopic versus open living donor right hepatectomy: propensity score-matched analysis.
Br J Surg. 2021 Jul 23;108(7):e233-e234. doi: 10.1093/bjs/znab090.
2
Laparoscopic Living Donor Right Hepatectomy Regarding the Anatomical Variation of the Portal Vein: A Propensity Score-Matched Analysis.腹腔镜活体供肝右半肝切除术与门静脉解剖变异:倾向评分匹配分析。
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World Survey on Minimally Invasive Donor Hepatectomy: A Global Snapshot of Current Practices in 2370 Cases.微创供体肝切除术全球调查:2370例病例的全球现行做法概况
Transplantation. 2022 Jan 1;106(1):96-105. doi: 10.1097/TP.0000000000003680.
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Expert Consensus Guidelines on Minimally Invasive Donor Hepatectomy for Living Donor Liver Transplantation From Innovation to Implementation: A Joint Initiative From the International Laparoscopic Liver Society (ILLS) and the Asian-Pacific Hepato-Pancreato-Biliary Association (A-PHPBA).微创供肝切取用于活体肝移植的专家共识指南:从创新到实施:国际腹腔镜肝脏学会(ILLS)和亚太肝脏病学、胆胰学和肝脏移植学会(A-PHPBA)的联合倡议。
Ann Surg. 2021 Jan 1;273(1):96-108. doi: 10.1097/SLA.0000000000004475.
7
Long-Term Safety and Efficacy of Pure Laparoscopic Donor Hepatectomy in Pediatric Living Donor Liver Transplantation.小儿活体肝移植中纯腹腔镜供肝切除术的长期安全性和有效性。
Liver Transpl. 2021 Apr;27(4):513-524. doi: 10.1002/lt.25910. Epub 2020 Dec 12.
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Robotic Versus Open Right Lobe Donor Hepatectomy for Adult Living Donor Liver Transplantation: A Propensity Score-Matched Analysis.机器人辅助与开放性右半肝供肝切取术在成人活体肝移植中的应用:倾向评分匹配分析。
Liver Transpl. 2020 Nov;26(11):1455-1464. doi: 10.1002/lt.25820. Epub 2020 Oct 7.
9
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