Xiao Zhe-Hao, Wang Cheng, Wang Yong, Yuan Shang-Kun, Huang Cheng, Chen Ren-Fang, Li Yong
Department of medical oncology, The First Affiliated Hospital of Nanchang University, Nanchang, China.
Emergency Department, The Second Affiliated Hospital of Nanchang University, Nanchang, China.
Endocr Pract. 2023 Sep;29(9):699-704. doi: 10.1016/j.eprac.2023.06.005. Epub 2023 Jun 19.
To compare the incidence of cancer in patients with acromegaly with that of the local population in China and explore possible risk factors.
Data from 117 patients diagnosed with acromegaly at 2 centers between 2011 and 2022 were analyzed, and their cancer diagnoses were recorded. The cancer standardized incidence ratios (SIRs) and 95% confidence intervals (CIs) were calculated by comparison with those of the local population. The patients were divided into 2 groups, having cancer diagnosis or not. The relationships between cancer and sex, body mass index, age, growth hormone levels, diagnosis delay, tumor size, disease duration, treatment, disease status, and other comorbidities were analyzed.
Eight (6.8%) of 117 patients were diagnosed with cancer. The incidence of overall (SIR = 3.29, 95% CI = 1.42-6.94), colorectal (SIR = 16.67, 95% CI = 4.45-42.67), and thyroid cancers (SIR = 14.29, 95% CI = 1.73-51.60) was increased, but that of lung cancer (SIR = 4.17, 95% CI = 0.50-15.05) was not. Diagnostic delay (10.1[8.6-14.3] vs 3.8[1.3-9.0]; P = .005) and duration of acromegaly (12.8[8.9-16.4] vs 5.6[2.3-10.9]; P = .008) were prolonged in the cancer group. Diabetes mellitus (odds ratio = 7.01, 95% CI = 1.23-39.99) was an independent risk factor for acromegaly with cancer.
Acromegaly patients are at a higher risk of cancer and its association with diabetes mellitus. Considering the rarity of the disease, an Acromegaly Cancer Registry Center should be established in China as soon as possible.
比较中国肢端肥大症患者与当地人群的癌症发病率，并探讨可能的危险因素。
分析了2011年至2022年间在2个中心诊断为肢端肥大症的117例患者的数据，并记录了他们的癌症诊断情况。通过与当地人群进行比较，计算癌症标准化发病率（SIR）和95%置信区间（CI）。将患者分为有癌症诊断和无癌症诊断两组。分析癌症与性别、体重指数、年龄、生长激素水平、诊断延迟、肿瘤大小、病程、治疗、疾病状态及其他合并症之间的关系。
117例患者中有8例（6.8%）被诊断为癌症。总体癌症（SIR = 3.29，95% CI = 1.42 - 6.94）、结直肠癌（SIR = 16.67，95% CI = 4.45 - 42.67）和甲状腺癌（SIR = 14.29，95% CI = 1.73 - 51.60）的发病率升高，但肺癌（SIR = 4.17，95% CI = 0.50 - 15.05）的发病率未升高。癌症组的诊断延迟（10.1[8.6 - 14.3]对3.8[1.3 - 9.0]；P = 0.005）和肢端肥大症病程（12.8[8.9 - 16.4]对5.6[2.3 - 1有癌症的肢端肥大症患者的独立危险因素。
肢端肥大症患者患癌症的风险较高，且与糖尿病有关。考虑到该疾病的罕见性，中国应尽快建立肢端肥大症癌症登记中心。.9]；P = 0.008）延长。糖尿病（优势比 = 7.01，95% CI = 1.23 - 39.99）是肢端肥大症合并癌症的独立危险因素。
肢端肥大症患者患癌症的风险较高，且与糖尿病有关。考虑到该疾病的罕见性，中国应尽快建立肢端肥大症癌症登记中心。
