School of Chemistry, The University of Sydney, Eastern Avenue, Sydney, NSW 2006, Australia.
J Mater Chem B. 2023 Jul 19;11(28):6516-6526. doi: 10.1039/d3tb00991b.
Protein cages and virus-like particles are often thought of as highly uniform structures that obey strict geometric rules for self-assembly. Yet, there is a growing number of examples where different architectures can emerge from the same native cage system through minor changes in experimental conditions or protein sequence. Access to diverse architectures can help tune the engineering of protein cages for biotechnology applications where shape and symmetry often affects function. In this review, we highlight the underappreciated diversity of polymorphic architectures that can be formed by protein cages and virus-like particles, categorising examples by their method of formation.
蛋白质笼和类病毒颗粒通常被认为是具有高度均匀结构的物质，它们遵循严格的几何规则进行自组装。然而，越来越多的例子表明，通过实验条件或蛋白质序列的微小改变，相同的天然笼系统可以产生不同的结构。获得不同的结构可以帮助调整蛋白质笼的工程设计，使其应用于生物技术领域，在该领域中形状和对称性通常会影响功能。在这篇综述中，我们强调了蛋白质笼和类病毒颗粒形成的多态结构的多样性，根据其形成方法对这些例子进行了分类。
