College of Chemistry & Pharmacy, Northwest A&F University, , Yangling, Shaanxi 712100, P. R. China.
ACS Appl Mater Interfaces. 2023 Jul 5;15(26):32047-32056. doi: 10.1021/acsami.3c06150. Epub 2023 Jun 22.
Microsphere arrays have significant applications and broad development prospects in various fields and disciplines. The simple, efficient, low-cost, automatic, and controllable preparation of microsphere arrays in multiple dimensions and morphologies is still a significant challenge. Here, a novel microsphere array direct writing technology was developed using a low-cost portable droplet microfluidic device and a high-precision movable platform. The proposed technology provided a powerful platform for the direct-writing preparation of microsphere arrays and was successfully applied to the precise and controllable fabrication of microsphere arrays with different sizes, shapes, structures, and arrangements. Additionally, gel microsphere arrays with metal ion patterns were fabricated using the microsphere arrays as templates and exhibited excellent performance in the visual analytical detection of heavy metal ions. Moreover, the simulated microsphere arrays offer a promising platform for rapidly generating high-viability and uniform 3D tumor spheroids. Therefore, given the superiority of this technology and the great potential of microsphere arrays, this simple high-speed microsphere array direct writing technology has a promising application in the multidisciplinary intersection of chemical, biological, and material sciences.
微球阵列在各个领域和学科中具有重要的应用和广阔的发展前景。然而，如何简单、高效、低成本、自动化且可控地制备多维度和多种形貌的微球阵列仍然是一个重大挑战。在这里，我们开发了一种使用低成本便携式液滴微流控装置和高精度可移动平台的新型微球阵列直写技术。所提出的技术为微球阵列的直接书写制备提供了强大的平台，并成功应用于不同尺寸、形状、结构和排列的微球阵列的精确和可控制造。此外，我们使用微球阵列作为模板制备了具有金属离子图案的凝胶微球阵列，该阵列在重金属离子的可视化分析检测中表现出优异的性能。此外，模拟微球阵列为快速生成高活力和均匀的 3D 肿瘤球体提供了有前景的平台。因此，鉴于该技术的优越性和微球阵列的巨大潜力，这种简单的高速微球阵列直写技术在化学、生物和材料科学的多学科交叉领域具有广阔的应用前景。
