Sindhe Haritha, Reddy Malladi Mounika, Rajkumar Karthikeyan, Kamble Akshay, Singh Amardeep, Kumar Anand, Sharma Satyasheel
Department of Medicinal Chemistry, National Institute of Pharmaceutical Education and Research - Ahmedabad, Gandhinagar, Gujarat, 382355, India.
Department of Natural Products, National Institute of Pharmaceutical Education and Research - Ahmedabad, Gandhinagar, Gujarat, 382355, India.
Beilstein J Org Chem. 2023 Jun 12;19:820-863. doi: 10.3762/bjoc.19.62. eCollection 2023.
Pyridine is a crucial heterocyclic scaffold that is widely found in organic chemistry, medicines, natural products, and functional materials. In spite of the discovery of several methods for the synthesis of functionalized pyridines or their integration into an organic molecule, new methodologies for the direct functionalization of pyridine scaffolds have been developed during the past two decades. In addition, transition-metal-catalyzed C-H functionalization and rare earth metal-catalyzed reactions have flourished over the past two decades in the development of functionalized organic molecules of concern. In this review, we discuss recent achievements in the transition-metal and rare earth metal-catalyzed C-H bond functionalization of pyridine and look into the mechanisms involved.
吡啶是一种至关重要的杂环骨架，广泛存在于有机化学、药物、天然产物和功能材料中。尽管已发现多种合成功能化吡啶或将其整合到有机分子中的方法，但在过去二十年中仍开发出了吡啶骨架直接功能化的新方法。此外，在过去二十年中，过渡金属催化的C-H官能化和稀土金属催化的反应在相关功能化有机分子的开发中蓬勃发展。在本综述中，我们讨论了过渡金属和稀土金属催化的吡啶C-H键官能化的最新成果，并探究其中涉及的机理。
