College of Public Health, Zhengzhou University, Zhengzhou, Henan, 450001, People's Republic of China.
Department of Chemistry and Biochemistry, St Mary's University, San Antonio, TX, USA.
Environ Sci Pollut Res Int. 2023 Jul;30(35):83113-83137. doi: 10.1007/s11356-023-27755-y. Epub 2023 Jun 22.
Endocrine disrupting chemicals (EDCs) are increasingly concerned substance endangering human health and environment. However, there is no unified standard for identifying chemicals as EDCs, which is also controversial internationally. In this review, the procedures for EDC identification in different organizations/countries were described. Importantly, three aspects to be considered in identifying chemical substances as EDCs were summarized, which were mechanistic data, animal experiments, and epidemiological information. The relationships between them were also discussed. To elaborate more clearly on these three aspects of evidence, scientific data on some chemicals including bisphenol A, 1,2-dibromo-4-(1,2 dibromoethyl) cyclohexane and perchlorate were collected and evaluated. Altogether, the above three chemicals were assessed for interfering with hormones and elaborated their health hazards from macroscopic to microscopic. This review is helpful for standardizing the identification procedure of EDCs.
内分泌干扰化学物质（EDCs）是越来越受到关注的危害人类健康和环境的物质。然而，目前还没有统一的标准来识别 EDCs，这在国际上也是有争议的。在这篇综述中，描述了不同组织/国家识别 EDC 的程序。重要的是，总结了识别 EDC 化学物质时需要考虑的三个方面，即机制数据、动物实验和流行病学信息。还讨论了它们之间的关系。为了更清楚地阐述这三个方面的证据，收集并评估了一些化学物质的科学数据，包括双酚 A、1,2-二溴-4-(1,2-二溴乙基)环己烷和高氯酸盐。总的来说，这三种化学物质被评估为干扰激素，并从宏观到微观详细阐述了它们的健康危害。这篇综述有助于规范 EDC 的识别程序。
