对可能影响[F]FDG放射化学合成产率的因素进行评估。

Evaluation of factors with potential influence on [F]FDG radiochemical synthesis yield.

作者信息

Chochevska Maja, Velichkovska Maja, Atanasova Lazareva Marija, Kolevska Katerina, Jolevski Filip, Razmoska Jasmina, Filipovski Zlatko, Nikolovski Sasho, Zdraveska Kocovska Marina, Ugrinska Ana

机构信息

University Institute of Positron Emission Tomography, Skopje, Macedonia; Faculty of Medical Science, University "Goce Delchev", Shtip, Macedonia.

出版信息

Appl Radiat Isot. 2023 Sep;199:110900. doi: 10.1016/j.apradiso.2023.110900. Epub 2023 Jun 14.

DOI:10.1016/j.apradiso.2023.110900

PMID:37348257

Abstract

[F]FDG radiopharmaceutical production is performed with automatic synthesis modules, which enables to carry out the production process safely, reliably and reproducibly. This study aimed to investigate the factors which may influence and give inconsistent radiochemical synthesis yield, as well as common pitfalls in the synthesis process which can occur. We evaluated more than 500 batches in the overall study. The results confirmed that irradiation parameter affect the production yield of the final product, also transport capillary capability and some synthesis factors have an impact on [F]FDG radiochemical synthesis yield.

摘要

[F]氟代脱氧葡萄糖（FDG）放射性药物的生产是通过自动合成模块进行的，这使得能够安全、可靠且可重复地开展生产过程。本研究旨在调查可能影响放射性化学合成产率并导致其不一致的因素，以及合成过程中可能出现的常见失误。在整个研究中，我们评估了500多批次。结果证实，辐照参数会影响最终产品的产量，运输毛细管性能和一些合成因素也会对[F]FDG放射性化学合成产率产生影响。