Key Laboratory of Microbial Technology for Industrial Pollution Control of Zhejiang Province, College of Environment, Zhejiang University of Technology, Hangzhou 310014, China.
Key Laboratory of Microbial Technology for Industrial Pollution Control of Zhejiang Province, College of Environment, Zhejiang University of Technology, Hangzhou 310014, China.
J Hazard Mater. 2023 Sep 15;458:131721. doi: 10.1016/j.jhazmat.2023.131721. Epub 2023 Jun 15.
Cypermethrin (CP), widely used as a broad-spectrum pesticide, has raised concerns over its frequent presence in the environment and potential health risks. The present study focused on incorporating the gut-organ axis theory to reinterpret the toxicological effects and mechanisms following CP exposure at environmentally relevant concentrations (0.1 mg/kg/d and 0.5 mg/kg/d) in pubertal male rats. The results showed alterations in histopathological and organosomatic indices in the liver, brain, and epididymis. Through multiomics network analysis, it was found that Lachnospiraceae and Ruminococcaceae may contribute to the alteration in serum L-carnitine and trigonelline, leading to hepatic lipid accumulation following CP exposure. Additionally, Ruminococcaceae, Lachnospiraceae, and Porphyromonadaceae were associated with CP-induced glutamatergic hypofunction and overproduction of TNF-α, potentially contributing to the brain neurotoxicity. Overall, the study provides important insights into the potential mechanisms underlying CP-induced toxicity and highlights the need for continued research to fully understand the implications for CP-induced health risks. The incorporation of the gut-organ axis theory in the study provides a promising avenue for future research into the potential interactions between gut microbiota and organ toxicity, and the potential for targeted interventions to mitigate the adverse effects of environmental toxins.
氯菊酯（CP）作为一种广泛使用的广谱杀虫剂，由于其在环境中的频繁存在及其潜在的健康风险而引起关注。本研究聚焦于将肠道-器官轴理论纳入其中，以重新解释在青春期雄性大鼠中以环境相关浓度（0.1mg/kg/d 和 0.5mg/kg/d）暴露于 CP 后的毒理学效应和机制。结果显示，CP 暴露导致肝脏、大脑和附睾的组织病理学和器官体指数发生改变。通过多组学网络分析，发现lachnospiraceae 和 ruminococcaceae 可能有助于改变血清肉毒碱和瓜氨酸，导致 CP 暴露后肝脏脂质积累。此外，ruminococcaceae、lachnospiraceae 和 porphyromonadaceae 与 CP 诱导的谷氨酸能功能低下和 TNF-α的过度产生有关，可能导致大脑神经毒性。总体而言，该研究为 CP 诱导毒性的潜在机制提供了重要见解，并强调需要继续研究，以充分了解 CP 诱导的健康风险的影响。将肠道-器官轴理论纳入研究中，为未来研究肠道微生物群和器官毒性之间的潜在相互作用以及针对干预措施以减轻环境毒素的不良影响提供了一个有前途的途径。
