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A negative trial for vasoactive intestinal peptide in COVID-19-associated acute hypoxaemic respiratory failure.

作者信息

Lee Warren L, Slutsky Arthur S

机构信息

Interdepartmental Division of Critical Care Medicine, University of Toronto, Toronto, ON M5S 1A1, Canada; Department of Laboratory Medicine and Pathology, University of Toronto, Toronto, ON M5S 1A1, Canada; Keenan Research Centre for Biomedical Science, Li Ka Shing Knowledge Institute, St Michael's Hospital, Unity Health Toronto, Toronto, ON M5B 1T8, Canada.

Interdepartmental Division of Critical Care Medicine, University of Toronto, Toronto, ON M5S 1A1, Canada; Keenan Research Centre for Biomedical Science, Li Ka Shing Knowledge Institute, St Michael's Hospital, Unity Health Toronto, Toronto, ON M5B 1T8, Canada.

出版信息

Lancet Respir Med. 2023 Sep;11(9):759-760. doi: 10.1016/S2213-2600(23)00218-7. Epub 2023 Jun 19.

DOI:10.1016/S2213-2600(23)00218-7
PMID:37348523
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10278994/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a49d/10278994/d54d1e0da3ec/fx1_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a49d/10278994/d54d1e0da3ec/fx1_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a49d/10278994/d54d1e0da3ec/fx1_lrg.jpg

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[1]
A negative trial for vasoactive intestinal peptide in COVID-19-associated acute hypoxaemic respiratory failure.

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[6]
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[7]
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[8]
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[9]
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[10]
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本文引用的文献

[1]
Intravenous aviptadil and remdesivir for treatment of COVID-19-associated hypoxaemic respiratory failure in the USA (TESICO): a randomised, placebo-controlled trial.

Lancet Respir Med. 2023-9

[2]
The Use of IV Vasoactive Intestinal Peptide (Aviptadil) in Patients With Critical COVID-19 Respiratory Failure: Results of a 60-Day Randomized Controlled Trial.

Crit Care Med. 2022-11-1

[3]
VIP plasma levels associate with survival in severe COVID-19 patients, correlating with protective effects in SARS-CoV-2-infected cells.

J Leukoc Biol. 2022-5

[4]
A Randomized Trial of Convalescent Plasma in Covid-19 Severe Pneumonia.

N Engl J Med. 2021-2-18

[5]
Remdesivir in adults with severe COVID-19: a randomised, double-blind, placebo-controlled, multicentre trial.

Lancet. 2020-4-29

[6]
Inflammation without Vascular Leakage. Science Fiction No Longer?

Am J Respir Crit Care Med. 2019-12-15

[7]
Dysregulation of JAK/STAT genes by vasoactive intestinal peptide (VIP) in Salmonella-infected monocytes may inhibit its therapeutic potential in human sepsis.

Cytokine. 2018-2-16

[8]
Perspective on optimizing clinical trials in critical care: how to puzzle out recurrent failures.

J Intensive Care. 2016-11-4

[9]
Cutting edge: vasoactive intestinal peptide acts as a potent suppressor of inflammation in vivo by trans-deactivating chemokine receptors.

J Immunol. 2003-11-15

[10]
Inhibition of IFN-gamma-induced janus kinase-1-STAT1 activation in macrophages by vasoactive intestinal peptide and pituitary adenylate cyclase-activating polypeptide.

J Immunol. 2000-9-15

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