也许各种形式的肾病在机制上并没有那么不同？

Maybe the various forms of kidney disease are not so mechanistically different?

机构信息

Cardiovascular Disease Program, Biomedicine Discovery Institute, Monash University, Melbourne, Victoria, Australia; Department of Physiology, Monash University, Melbourne, Victoria, Australia; Pre-clinical Critical Care Unit, Florey Institute of Neuroscience and Mental Health, University of Melbourne, Melbourne, Victoria, Australia.

出版信息

Kidney Int. 2023 Jul;104(1):31-33. doi: 10.1016/j.kint.2023.04.014.

DOI:10.1016/j.kint.2023.04.014

PMID:37349058

Abstract

Sieckmann and colleagues provide evidence of a common abnormality in polyamine metabolism in 11 different rodent models of acute kidney injury and chronic kidney disease, and in human renal transplantation. The abnormality is characterized by downregulation of enzymes involved in polyamine synthesis and/or upregulation of enzymes involved in polyamine metabolism. Therefore, polyamine metabolism is a potential target for development of pharmacotherapies for a broad range of kidney diseases.

摘要

Sieckmann 及其同事在 11 种不同的急性肾损伤和慢性肾脏病的啮齿动物模型以及人类肾移植中提供了多胺代谢中常见异常的证据。这种异常的特征是多胺合成相关酶的下调和/或多胺代谢相关酶的上调。因此，多胺代谢是为广泛的肾脏疾病开发药物治疗的潜在靶点。