Wallis J W, Wu-Connolly L, Rocchini A P, Juni J E
J Nucl Med. 1986 Aug;27(8):1347-52.
Normal resting heart rate variations distort the diastolic portions of left ventricular time-activity curves, altering calculated measures of diastolic function such as peak filling rate. Diastolic filling parameters obtained by two methods of arrhythmia removal--list-mode acquisition and a new approach, dynamic arrhythmia filtration (DAF)--were compared. In DAF, data are evaluated for cycle length in real time and accepted or rejected immediately according to preset, operator-determined cycle-length criteria, eliminating the need for postprocessing of data and for large mass data storage. We prospectively determined EF, time to end-systole, peak filling rate, and time to peak filling on gated blood-pool studies of 25 patients. Identical camera and ECG data were sent simultaneously to two computers and analyzed using list mode and DAF, with an R-R interval of 5-6% of mean heart rate. Excellent correlation between list mode and DAF was seen in peak filling rate (r = 0.94), EF (r = 0.99), and time to end-systole (r = 0.97). Lesser correlation seen in time to peak filling (r = 0.65) may be due to inherent problems in measuring this parameter reliably, possibly lessening this parameter's clinical usefulness. DAF is less time consuming and less technically demanding than list mode, and provides results which correlate closely to those obtained by list mode.
正常静息心率变化会使左心室时间-活动曲线的舒张期部分失真，从而改变诸如峰值充盈率等舒张功能的计算指标。比较了通过两种心律失常去除方法——列表模式采集和一种新方法动态心律失常过滤（DAF）——获得的舒张期充盈参数。在DAF中，实时评估数据的心动周期长度，并根据预设的、由操作员确定的心动周期长度标准立即接受或拒绝数据，从而无需对数据进行后处理以及大量数据存储。我们前瞻性地测定了25例患者门控心血池研究中的射血分数（EF）、收缩末期时间、峰值充盈率和峰值充盈时间。相同的相机和心电图数据同时发送到两台计算机，并分别使用列表模式和DAF进行分析，平均心率的R-R间期设定为5%-6%。列表模式和DAF在峰值充盈率（r = 0.94）、EF（r = 0.99）和收缩末期时间（r = 0.97）方面具有极好的相关性。峰值充盈时间的相关性较低（r = 0.65），可能是由于可靠测量该参数存在固有问题，这可能降低了该参数的临床实用性。与列表模式相比，DAF耗时更少，技术要求更低，且提供的结果与列表模式获得的结果密切相关。
