Keita Hawa, Meek Simon J
Department of Chemistry, University of North Carolina at Chapel Hill, 27599-3290, Chapel Hill, NC, USA.
Angew Chem Int Ed Engl. 2023 Aug 21;62(34):e202306277. doi: 10.1002/anie.202306277. Epub 2023 Jul 11.
A practical method for the preparation of quaternary and tertiary allyl-substituted heteroarenes by site-selective couplings of heteroaryl nitriles and allylic nucleophiles is disclosed. Transformations utilize readily accessible stable reagents, proceed in the presence of a Lewis base activator, and undergo aryl-C(sp ) quaternary and tertiary carbon formation with high γ-selectivity (up to >98 : 2 γ : α).
公开了一种通过杂芳基腈与烯丙基亲核试剂的位点选择性偶联制备季铵化和叔烯丙基取代杂芳烃的实用方法。该转化反应使用易于获得的稳定试剂,在路易斯碱活化剂存在下进行,并以高γ选择性(高达>98:2γ:α)形成芳基-C(sp)季碳和叔碳。