Department of Cardiology, Institute of Cardiovascular Diseases, First Affiliated Hospital of Dalian Medical University, Dalian, China.
Health Department of Kailuan Group, Tangshan, China.
Cancer Med. 2023 Aug;12(15):16580-16590. doi: 10.1002/cam4.6251. Epub 2023 Jun 23.
There is limited evidence on the association between arterial stenosis and the risk of all-cause mortality in cancer patients (ACMC). This study investigated whether the status of arterial function and structure measured by brachial-ankle pulse wave velocity (baPWV) is associated with ACMC.
A total of 43,943 Chinese adults underwent a baPWV examination. Cox proportional hazards model was used to assess the association between the baPWV values and ACMC.
During a total follow-up duration of 3.81 ± 2.50 years, there were 157 deaths among 553 cancer cases diagnosed during the follow-up. Patients with baPWV ≥18 m/s showed an increased risk of ACMC compared to patients with ideal vascular function. In the multivariate-adjusted model, we observed a significant association between arterial stiffness severity and ACMC with a hazard ratio (HR) 2.72 (95% confidence interval [CI]: 1.55-4.80; p < 0.001) in those with baPWV ≥18 m/s. With a 1-SD increase in baPWV, the HR (95% CI) for ACMC in the entire cohort, men, and patients ≤60 years old were 1.20 (95% CI: 1.03-1.41; p < 0.05), 1.20 (95% CI: 1.01-1.43; p < 0.05), and 1.44 (95% CI: 1.10-1.44; p = 0.008), respectively.
Increased arterial stiffness measured by baPWV is associated with ACMC. The association between high baPWV (≥18 m/s) and risk of all-cause mortality was prominent in men and those ≤60 years of age.
目前关于动脉狭窄与癌症患者全因死亡率（ACMC）之间的关系的证据有限。本研究旨在探讨肱踝脉搏波速度（baPWV）测量的动脉功能和结构状态是否与 ACMC 相关。
共有 43943 名中国成年人接受了 baPWV 检查。采用 Cox 比例风险模型评估 baPWV 值与 ACMC 之间的关系。
在总随访时间为 3.81±2.50 年期间，在随访期间诊断出 553 例癌症患者中有 157 例死亡。与具有理想血管功能的患者相比，baPWV≥18m/s 的患者 ACMC 风险增加。在多变量调整模型中，我们观察到动脉僵硬严重程度与 ACMC 之间存在显著关联，baPWV≥18m/s 的患者风险比（HR）为 2.72（95%置信区间[CI]：1.55-4.80；p<0.001）。在整个队列、男性和≤60 岁的患者中，baPWV 每增加 1-SD，ACMC 的 HR（95%CI）分别为 1.20（95%CI：1.03-1.41；p<0.05）、1.20（95%CI：1.01-1.43；p<0.05）和 1.44（95%CI：1.10-1.44；p=0.008）。
baPWV 测量的动脉僵硬程度增加与 ACMC 相关。baPWV（≥18m/s）升高与全因死亡率风险之间的关联在男性和≤60 岁的人群中更为显著。
