动脉僵硬度与癌症发生之间的关联：来自开滦队列研究的数据。
The association between arterial stiffness and cancer occurrence: Data from Kailuan cohort study.
作者信息
Jiang Yinong, Xing Aijun, Hidru Tesfaldet Habtemariam, Li Jiatian, Yang Xiaolei, Chen Shuohua, Xia Yun-Long, Wu Shouling
机构信息
Department of Cardiology, Institute of Cardiovascular Diseases, First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning, China.
Department of Cardiology, Kailuan General Hospital, North China University of Science and Technology, Tangshan, Hebei, China.
出版信息
Front Cardiovasc Med. 2023 Mar 1;10:1112047. doi: 10.3389/fcvm.2023.1112047. eCollection 2023.
BACKGROUND
This study aimed to investigate whether increased arterial stiffness, measured by brachial-ankle pulse wave velocity (baPWV) is associated with cancer.
MATERIALS AND METHODS
A total of 45,627 Chinese adults underwent a baPWV examination. The participants were followed up from 1st January 2012 to 31st December 2018. Cox proportional hazards model was used to assess the association between the baPWV values and cancer.
RESULTS
During a total follow-up duration of 172,775.69 person-years, there were 553 new cases of cancer. The subjects in the highest baPWV group showed an increased risk of cancer when compared with the lowest baPWV group as confirmed by multivariate-adjusted hazard ratios (HR = 1.51, 95% CI = 1.14∼2.00) in the entire cohort. Compared with participants in the lowest baPWV group, the HRs (95% CI) for digestive cancer in the second and third groups were 1.55 (1.00∼2.40) and 1.99 (1.19∼3.33), respectively. The Kaplan-Meier analysis demonstrated a significant increase in cancer in participants with a baPWV ≥ 18 m/s ( < 0.001). Compared with the lowest baPWV group, the highest baPWV group showed an increased risk of cancer in men (HR = 1.72, 95% CI = 1.22∼2.43) and those < 60 years (HR = 1.75, 95% CI = 1.20∼2.55), respectively.
CONCLUSION
Increased arterial stiffness measured by baPWV is associated with cancer occurrence, especially digestive cancer occurrence.
CLINICAL TRIAL REGISTRATION
ClinicalTrials.gov, identifier ChiCTR-TNRC-11001489.
背景
本研究旨在调查通过肱踝脉搏波速度（baPWV）测量的动脉僵硬度增加是否与癌症相关。
材料与方法
共有45627名中国成年人接受了baPWV检查。参与者从2012年1月1日至2018年12月31日进行随访。采用Cox比例风险模型评估baPWV值与癌症之间的关联。
结果
在总计172775.69人年的随访期间，有553例新发癌症病例。在整个队列中，经多变量调整的风险比（HR = 1.51，95%CI = 1.14∼2.00）证实，baPWV最高组的受试者与最低组相比，患癌风险增加。与baPWV最低组的参与者相比，第二组和第三组消化癌的HR（95%CI）分别为1.55（1.00∼2.40）和1.99（1.19∼3.33）。Kaplan-Meier分析表明，baPWV≥18 m/s的参与者患癌率显著增加（<0.001）。与baPWV最低组相比，baPWV最高组男性（HR = 1.72，95%CI = 1.22∼2.43）和60岁以下人群（HR = 1.75，95%CI = 1.20∼2.55）患癌风险增加。
结论
通过baPWV测量的动脉僵硬度增加与癌症发生相关，尤其是消化癌的发生。
临床试验注册
ClinicalTrials.gov，标识符ChiCTR-TNRC-11001489。
Zotero 插件