MXenes-Au NPs 修饰电化学生物传感器用于多种外泌体表面蛋白分析。
MXenes-Au NPs modified electrochemical biosensor for multiple exosome surface proteins analysis.
机构信息
Department of Clinical Laboratory, Shanghai Pudong Hospital, Fudan University Pudong Medical Center, Shanghai, 201399, China.
Department of Clinical Laboratory, Huashan Hospital, Fudan University, Shanghai, 200040, China.
出版信息
Talanta. 2023 Dec 1;265:124848. doi: 10.1016/j.talanta.2023.124848. Epub 2023 Jun 20.
As a novel class of non-invasive biomarkers, exosome-carried proteins are essential in early detection and precise cancer diagnosis. In the study, we developed an electrochemical biosensor based on MXenes-Au NPs modification to assess the differential expression of EGFR, CEA, and EpCAM proteins of exosomes. This sensor has sensitively detected tumor biomarkers in the exosomes generated by various tumor cells (including A549, MCF-7, PC-3, and HeLa). Building a biosensor that can distinguish minute differences of proteins in various derived-from exosomes is crucial for addressing the issues with early and accurate cancer detection.
作为一类新型的非侵入性生物标志物，外泌体携带的蛋白质在早期检测和精确癌症诊断中至关重要。在这项研究中，我们开发了一种基于 MXenes-Au NPs 修饰的电化学生物传感器，以评估外泌体中 EGFR、CEA 和 EpCAM 蛋白的差异表达。该传感器能够灵敏地检测来自各种肿瘤细胞（包括 A549、MCF-7、PC-3 和 HeLa）的外泌体中的肿瘤生物标志物。构建一个能够区分各种来源的外泌体中蛋白质微小差异的生物传感器，对于解决早期和准确癌症检测的问题至关重要。
Zotero 插件