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纳米材料促进了电化学微小RNA生物传感器的快速发展。

Nanomaterials promote the fast development of electrochemical MiRNA biosensors.

作者信息

Ouyang Ruizhuo, Huang Ying, Ma Yuanhui, Feng Meina, Liu Xi, Geng Chongrui, Zhao Yuefeng, Zhou Shuang, Liu Baolin, Miao Yuqing

机构信息

Institute of Bismuth and Rhenium Science, University of Shanghai for Science and Technology Shanghai 200093 China

Cancer Institute, Tongji University School of Medicine Shanghai 200093 China.

出版信息

RSC Adv. 2024 Jun 4;14(25):17929-17944. doi: 10.1039/d3ra08258j. eCollection 2024 May 28.

DOI:10.1039/d3ra08258j
PMID:38836170
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11149695/
Abstract

Cancer has become the leading cause of death worldwide. In recent years, molecular diagnosis has demonstrated great potential in the prediction and diagnosis of cancer. MicroRNAs (miRNAs) are short oligonucleotides that regulate gene expression and cell function and are considered ideal biomarkers for cancer detection, diagnosis, and patient prognosis. Therefore, the specific and sensitive detection of ultra-low quantities of miRNA is of great significance. MiRNA biosensors based on electrochemical technology have advantages of high sensitivity, low cost and fast response. Nanomaterials show great potential in miRNA electrochemical detection and promote the rapid development of electrochemical miRNA biosensors. Some methods and signal amplification strategies for miRNA detection in recent years are reviewed herein, followed by a discussion of the latest progress in electrochemical miRNA detection based on different types of nanomaterial. Future perspectives and challenges are also proposed for further exploration of nanomaterials to bring breakthroughs in electrochemical miRNA detection.

摘要

癌症已成为全球主要死因。近年来，分子诊断在癌症的预测和诊断中显示出巨大潜力。微小RNA（miRNA）是一类短链寡核苷酸，可调节基因表达和细胞功能，被认为是癌症检测、诊断及患者预后评估的理想生物标志物。因此，超微量miRNA的特异性和灵敏检测具有重要意义。基于电化学技术的miRNA生物传感器具有灵敏度高、成本低、响应快等优点。纳米材料在miRNA电化学检测中展现出巨大潜力，推动了电化学miRNA生物传感器的快速发展。本文综述了近年来一些miRNA检测方法及信号放大策略，随后讨论了基于不同类型纳米材料的电化学miRNA检测的最新进展。还提出了未来展望和挑战，以便进一步探索纳米材料，在电化学miRNA检测方面取得突破。

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