溶剂依赖的铑催化三氟甲基烯烃的发散氢官能化反应。
Solvent-Dependent Rhodium-Catalyzed Divergent Hydrofunctionalization of Trifluoromethylalkenes.
机构信息
Normandie Université, INSA Rouen, UNIROUEN, CNRS, COBRA (UMR 6014), 76000 Rouen, France.
Hangzhou Normal University, Key Laboratory of Organosilicon Chemistry and Material Technology of Ministry of Education, 311121 Hangzhou, P. R. China.
出版信息
Org Lett. 2023 Jul 7;25(26):4928-4933. doi: 10.1021/acs.orglett.3c01754. Epub 2023 Jun 23.
We report a rhodium-catalyzed anti-Markovnikov regioselective hydrosilylation of trifluoromethylalkenes with substituted silanes giving various α-trifluoromethyl-β-silanes in good to excellent yields. The hydrogenation products were obtained via the same key intermediate treated with methanol as a protic solvent. Both transformations had a broad functional tolerance and were expected to facilitate the construction of complex α-trifluoromethyl compounds.
我们报告了一种铑催化的反马氏规则区域选择性三氟甲基烯烃与取代硅烷的氢硅化反应，以良好至优秀的收率得到了各种α-三氟甲基-β-硅烷。通过用甲醇作为质子溶剂处理相同的关键中间体，可以得到氢化产物。这两种转化都具有广泛的官能团容忍性，有望促进复杂的α-三氟甲基化合物的构建。
Zotero 插件