Department of Pediatric Hematology/Oncology/Stem Cell Transplantation, Medical City Children's Hospital, Dallas, TX, USA.
Department of Pediatrics, New York Medical College, Valhalla, NY, USA; Department of Pathology, New York Medical College, Valhalla, NY, USA; Department of Epidemiology and Community Health, New York Medical College, Valhalla, NY, USA; Department of Medicine, New York Medical College, Valhalla, NY, USA; Department of Microbiology and Immunology, New York Medical College, Valhalla, NY, USA; Department of Cell Biology and Anatomy, New York Medical College, Valhalla, NY, USA.
Best Pract Res Clin Haematol. 2023 Jun;36(2):101463. doi: 10.1016/j.beha.2023.101463. Epub 2023 Apr 2.
Mature B-cell lymphoma in children, adolescents and young adults comprises three major histological subtypes including in order of frequency Burkitt, germinal center diffuse large B-cell lymphoma and primary mediastinal B-cell lymphoma. The cure rate of the first two with aggressive short chemotherapy based on clinical grouping is ∼90% in resource rich countries. Recent data has shown that incorporation of immune therapy has enhanced event free survival in advanced patients. Future studies will address the possibility of reducing the burden of chemotherapy by substitution of immune based therapies.
儿童、青少年和青年的成熟 B 细胞淋巴瘤包括三种主要组织学亚型，按频率依次为伯基特淋巴瘤、生发中心弥漫性大 B 细胞淋巴瘤和原发性纵隔 B 细胞淋巴瘤。在资源丰富的国家，基于临床分组的强化短程化疗可使前两种类型的治愈率达到约 90%。最近的数据表明，免疫治疗的加入提高了晚期患者的无事件生存。未来的研究将探讨用免疫治疗替代化疗以减轻化疗负担的可能性。
