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Lack of disease control remains a major barrier to transplant for older patients with AML.缺乏疾病控制仍然是老年急性髓系白血病患者移植的主要障碍。
Bone Marrow Transplant. 2023 Sep;58(9):1054-1056. doi: 10.1038/s41409-023-02022-3. Epub 2023 Jun 23.
2
Effectiveness of allogeneic hematopoietic cell transplantation for older patients with acute myeloid leukemia.异基因造血细胞移植治疗老年急性髓系白血病的疗效。
Best Pract Res Clin Haematol. 2021 Dec;34(4):101320. doi: 10.1016/j.beha.2021.101320. Epub 2021 Oct 22.
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Impact of allogeneic hematopoietic cell transplantation on the outcome of older patients with acute myeloid leukemia.异基因造血细胞移植对老年急性髓系白血病患者预后的影响。
Best Pract Res Clin Haematol. 2017 Dec;30(4):320-326. doi: 10.1016/j.beha.2017.09.004. Epub 2017 Sep 22.
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Haploidentical Hematopoietic Cell Transplant with Post-Transplant Cyclophosphamide and Peripheral Blood Stem Cell Grafts in Older Adults with Acute Myeloid Leukemia or Myelodysplastic Syndrome.老年急性髓系白血病或骨髓增生异常综合征患者采用亲缘单倍体造血干细胞移植联合移植后环磷酰胺和外周血造血干细胞移植。
Biol Blood Marrow Transplant. 2017 Oct;23(10):1736-1743. doi: 10.1016/j.bbmt.2017.06.019. Epub 2017 Jul 5.
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Cytomegalovirus Reactivation after Allogeneic Hematopoietic Stem Cell Transplantation is Associated with a Reduced Risk of Relapse in Patients with Acute Myeloid Leukemia Who Survived to Day 100 after Transplantation: The Japan Society for Hematopoietic Cell Transplantation Transplantation-related Complication Working Group.异基因造血干细胞移植后巨细胞病毒再激活与移植后存活至第100天的急性髓系白血病患者复发风险降低相关：日本造血细胞移植学会移植相关并发症工作组
Biol Blood Marrow Transplant. 2015 Nov;21(11):2008-16. doi: 10.1016/j.bbmt.2015.07.019. Epub 2015 Jul 26.
6
Comparison of matched sibling donors versus unrelated donors in allogeneic stem cell transplantation for primary refractory acute myeloid leukemia: a study on behalf of the Acute Leukemia Working Party of the EBMT.原发性难治性急性髓系白血病异基因造血干细胞移植中匹配同胞供者与无关供者的比较：一项代表 EBMT 急性白血病工作组进行的研究。
J Hematol Oncol. 2017 Jun 24;10(1):130. doi: 10.1186/s13045-017-0498-8.
7
Consolidation chemotherapy prior to hematopoietic cell transplantation for adults with acute myeloid leukemia in first remission.首次缓解的成人急性髓系白血病患者造血细胞移植前的巩固化疗。
Best Pract Res Clin Haematol. 2016 Dec;29(4):365-371. doi: 10.1016/j.beha.2016.10.012. Epub 2016 Oct 19.
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Strategies to reduce relapse after allogeneic hematopoietic cell transplantation in acute myeloid leukemia.急性髓系白血病异基因造血细胞移植后降低复发的策略。
Curr Hematol Malig Rep. 2013 Jun;8(2):132-40. doi: 10.1007/s11899-013-0153-6.
9
[Hematopoietic stem cell transplantation for acute myeloid leukemia].[急性髓系白血病的造血干细胞移植]
Rinsho Ketsueki. 2016;57(10):1928-1933. doi: 10.11406/rinketsu.57.1928.
10
Allogeneic hematopoietic stem cell transplant overcomes poor prognosis of acute myeloid leukemia with myelodysplasia-related changes.异基因造血干细胞移植克服了伴有骨髓发育异常相关改变的急性髓系白血病的不良预后。
Leuk Lymphoma. 2016;57(1):76-80. doi: 10.3109/10428194.2015.1063148.

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Test Then Erase? Current Status and Future Opportunities for Measurable Residual Disease Testing in Acute Myeloid Leukemia.检测后清除？急性髓系白血病中可测量残留疾病检测的现状和未来机遇。
Acta Haematol. 2024;147(2):133-146. doi: 10.1159/000535463. Epub 2023 Nov 30.

本文引用的文献

1
Referral to and receipt of allogeneic hematopoietic stem cell transplantation in older adults with acute myeloid leukemia.老年急性髓系白血病患者接受异基因造血干细胞移植的转诊和接受情况。
J Geriatr Oncol. 2023 Jan;14(1):101403. doi: 10.1016/j.jgo.2022.11.002. Epub 2022 Nov 10.
2
Impact of MRD status in patients with AML undergoing allogeneic stem cell transplantation in the first vs the second remission.在首次缓解期和第二次缓解期接受异基因干细胞移植的 AML 患者中，MRD 状态的影响。
Blood Adv. 2022 Aug 9;6(15):4570-4580. doi: 10.1182/bloodadvances.2022007168.
3
Age is no barrier for adults undergoing HCT for AML in CR1: contemporary CIBMTR analysis.年龄不是 AML 处于 CR1 期行 HCT 成人的障碍：当代 CIBMTR 分析。
Bone Marrow Transplant. 2022 Jun;57(6):911-917. doi: 10.1038/s41409-022-01650-5. Epub 2022 Apr 2.
4
Measurable Residual Disease Response and Prognosis in Treatment-Naïve Acute Myeloid Leukemia With Venetoclax and Azacitidine.维奈托克联合阿扎胞苷治疗初治急性髓系白血病的微小残留病反应与预后。
J Clin Oncol. 2022 Mar 10;40(8):855-865. doi: 10.1200/JCO.21.01546. Epub 2021 Dec 15.
5
Impact of Conditioning Intensity of Allogeneic Transplantation for Acute Myeloid Leukemia With Genomic Evidence of Residual Disease.有残留疾病基因组证据的急性髓细胞性白血病异体移植的条件强度的影响。
J Clin Oncol. 2020 Apr 20;38(12):1273-1283. doi: 10.1200/JCO.19.03011. Epub 2019 Dec 20.
6
Increasing use of allogeneic hematopoietic cell transplantation in patients aged 70 years and older in the United States.在美国，70岁及以上患者中异基因造血细胞移植的使用越来越多。
Blood. 2017 Aug 31;130(9):1156-1164. doi: 10.1182/blood-2017-03-772368. Epub 2017 Jul 3.
7
Allogeneic hematopoietic cell transplantation for adults with acute myeloid leukemia: myths, controversies, and unknowns.成人急性髓系白血病的异基因造血细胞移植：误区、争议与未知。
Blood. 2011 Feb 24;117(8):2307-18. doi: 10.1182/blood-2010-10-265603. Epub 2010 Nov 22.
8
Effect of age on outcome of reduced-intensity hematopoietic cell transplantation for older patients with acute myeloid leukemia in first complete remission or with myelodysplastic syndrome.年龄对缓解后接受低强度造血细胞移植的老年急性髓系白血病或骨髓增生异常综合征患者的预后的影响。
J Clin Oncol. 2010 Apr 10;28(11):1878-87. doi: 10.1200/JCO.2009.25.4821. Epub 2010 Mar 8.
9
Access to hematopoietic cell transplantation in the United States.美国的造血细胞移植途径。
Biol Blood Marrow Transplant. 2010 Aug;16(8):1070-5. doi: 10.1016/j.bbmt.2009.12.529. Epub 2009 Dec 28.
10
High-resolution donor-recipient HLA matching contributes to the success of unrelated donor marrow transplantation.高分辨率的供受者人类白细胞抗原（HLA）配型有助于无关供者骨髓移植的成功。
Blood. 2007 Dec 15;110(13):4576-83. doi: 10.1182/blood-2007-06-097386. Epub 2007 Sep 4.

Lack of disease control remains a major barrier to transplant for older patients with AML.

作者信息

Jeng Mark Y, Kong Denice, Rajalingam Raja, Lin Richard J, Olin Rebecca L

机构信息

Division of Hematology and Oncology, Department of Medicine, University of California San Francisco, San Francisco, CA, USA.

Immunogenetics and Transplantation Laboratory, Department of Surgery, University of California San Francisco, San Francisco, CA, USA.

出版信息

Bone Marrow Transplant. 2023 Sep;58(9):1054-1056. doi: 10.1038/s41409-023-02022-3. Epub 2023 Jun 23.

DOI:10.1038/s41409-023-02022-3
PMID:37353571
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11022831/
Abstract
摘要