Department of Biochemistry, Faculty of Science, Port-Said University, Port Said, Egypt.
Internal Medicine Department, Oncology Center, Faculty of Medicine, Mansoura University, El Mansoura, Egypt.
BMC Cancer. 2023 Jun 23;23(1):584. doi: 10.1186/s12885-023-11071-2.
The study aimed to investigate the over expression of IFITM3 in hepatocellular carcinoma Egyptian patients.
Hepatocellular carcinoma (HCC) continues to be a serious disease burden. Interferon Induced Transmembrane protein 3 (IFITM3) is a protein that encoded in humans by the IFITM3 gene. It plays a critical role in the immune system's defense, responsible for a large portion of the antiviral activity. In this study, we showed that IFITM3 rs 12252-CC was over expressed in HCC patients compared to control group with HCV infection.
DNA sequencing was applied for detection of IFITM3 rs 12252-CC and IFITM3 protein level was measured by ELISA to 50 patients with HCC with cirrhosis and 50 with Hepatitis C virus infection.
The obtained results of this study indicated that IFITM3 rs 12252-CC was significantly elevated in HCC group, the codominant model of CC genotype of IFITM3 gene had high association with risk of hepatocellular carcinoma with odd ratio (OR) = 2.70, p = 0.041.
IFITM3 play an important role in progression of hepatocellular carcinoma. Results revealed that IFITM3 rs 12252-CC among Hepatocellular carcinoma patients would allow diagnosis and starting intervention.
本研究旨在探讨 IFITM3 在埃及肝细胞癌患者中的过度表达。
肝细胞癌（HCC）仍是一种严重的疾病负担。干扰素诱导跨膜蛋白 3（IFITM3）是一种在人类中由 IFITM3 基因编码的蛋白质。它在免疫系统的防御中起着至关重要的作用，负责大部分抗病毒活性。在这项研究中，我们表明 IFITM3 rs12252-CC 在 HCC 患者中过度表达，与 HCV 感染对照组相比。
应用 DNA 测序检测 IFITM3 rs12252-CC，并用 ELISA 法测量 50 例肝硬化 HCC 患者和 50 例丙型肝炎病毒感染患者的 IFITM3 蛋白水平。
本研究的结果表明，IFITM3 rs12252-CC 在 HCC 组中显著升高，IFITM3 基因 CC 基因型的共显性模型与肝细胞癌的风险高度相关，比值比（OR）=2.70，p=0.041。
IFITM3 在肝细胞癌的进展中起着重要作用。结果表明，IFITM3 rs12252-CC 在肝细胞癌患者中可以进行诊断和开始干预。
