三乙基氯化铅对δ-氨基乙酰丙酸脱水酶的影响。

Effect of triethyl lead chloride on delta-aminolevulinic acid dehydratase.

作者信息

Bondy S C

出版信息

J Toxicol Environ Health. 1986;18(4):639-49. doi: 10.1080/15287398609530900.

Abstract

The effect of various organic metal compounds on delta-aminolevulinic acid dehydratase (ALAD, porphobilinogen synthetase) activity has been studied. Various organic tin and lead compounds have little effect on this enzyme. However, triethyl lead chloride has a potency similar to that of inorganic lead nitrate in inhibiting ALAD both for in vitro study and after in vivo dosing. Liver and blood ALAD have a similar sensitivity to lead compounds, which is reduced in the presence of zinc. Trimethyl lead chloride inhibits ALAD in vitro to a lesser extent. The results suggest that amphiphilic organic lead compounds may directly inhibit ALAD without prior degradation to inorganic lead. The diffusibility and persistence of triethyl lead combine to make it an especially hazardous lead compound.

摘要

已研究了各种有机金属化合物对δ-氨基乙酰丙酸脱水酶（ALAD，胆色素原合成酶）活性的影响。各种有机锡和铅化合物对该酶影响很小。然而，三乙基氯化铅在体外研究和体内给药后对ALAD的抑制效力与无机硝酸铅相似。肝脏和血液中的ALAD对铅化合物具有相似的敏感性，在锌存在的情况下这种敏感性会降低。三甲基氯化铅在体外对ALAD的抑制作用较小。结果表明，两亲性有机铅化合物可能直接抑制ALAD，而无需先降解为无机铅。三乙基铅的扩散性和持久性使其成为一种特别危险的铅化合物。