Zareba G, Chmielnicka J
Ecotoxicol Environ Saf. 1985 Feb;9(1):40-6. doi: 10.1016/0147-6513(85)90032-6.
Ninety rats of the Wistar strain were divided into 18 groups (5 animals in each). Stannous chloride was administered to animals by different routes (subcutaneously, intraperitoneally, intragastrically). Zinc was given intraperitoneally and lead was given subcutaneously, both every other day. Control animals received 0.9% NaCl. Aminolevulinic acid dehydratase (ALAD) activity was clearly decreased due to the double tin dose (total dose 4 mg Sn/kg), whereas 7 doses (altogether 14 mg Sn/kg) resulted in almost complete enzyme inhibition. ALAD inhibition in rat blood was similar, whatever the SnCl2 administration route. Greater inhibition was noted when this enzyme measured at pH 6.8. Zinc administered intraperitoneally (without tin) was also found to inhibit ALAD activity. The zinc doses applied did not protect ALAD activity against inhibition by tin, administered either intragastrically or intraperitoneally.
将90只Wistar品系大鼠分为18组（每组5只）。通过不同途径（皮下、腹腔内、胃内）给动物施用氯化亚锡。每隔一天腹腔内注射锌，皮下注射铅。对照动物接受0.9%氯化钠。由于双倍锡剂量（总剂量4mg Sn/kg），氨基乙酰丙酸脱水酶（ALAD）活性明显降低，而7剂（共14mg Sn/kg）导致几乎完全的酶抑制。无论SnCl2的给药途径如何，大鼠血液中的ALAD抑制作用相似。当在pH 6.8测量该酶时，观察到更大的抑制作用。还发现腹腔内注射锌（无锡）也会抑制ALAD活性。所施用的锌剂量不能保护ALAD活性免受胃内或腹腔内施用的锡的抑制。
