Department of Chemistry, University of Saskatchewan, 110 Science Place, Room 165 Thorvaldson Building, Saskatoon, SK S7N 5C9, Canada; Department of Chemistry, McGill University, 801 Sherbrooke Street West, Montreal, QC H3A 0B8, Canada; Quebec Centre for Advanced Materials (QCAM) and Pulp and Paper Research Centre, McGill University, 3420 University Street, Montreal, QC H3A 2A7, Canada; Department of Chemistry, College of Science, Shahid Chamran University of Ahvaz, Ahvaz, Iran.
Department of Chemistry, University of Saskatchewan, 110 Science Place, Room 165 Thorvaldson Building, Saskatoon, SK S7N 5C9, Canada.
J Colloid Interface Sci. 2023 Nov;649:456-470. doi: 10.1016/j.jcis.2023.06.118. Epub 2023 Jun 19.
The engineering of a new monodisperse colloid with a sea urchin-like structure with a large complex internal structure is reported, in which silica surfaces are bridged by an aromatic organic cross-linker to serve as a nanocarrier host for drugs such as doxorubicin (DOX) against breast cancer cells. While dendritic fibrous nanosilica (DFNS) was employed and we do not observe a dendritic structure, these particles are referred to as sea urchin-like nanostructured silica (SNS). Since the structure of SNS consists of many silica fibrils protruding from the core, similar to the hairs of a sea urchin. For the aromatic structured cross-linker, bis(propyliminomethyl)benzene (b(PIM)B-S or silanated terephtaldehyde) were employed, which are prepared with terephtaldehyde and 3-aminopropyltriethoxy-silane (APTES) through a simple Schiff base reaction. b(PIM)B-S bridges were introduced into SNS under open vessel reflux conditions. SPS refers to the product obtained by incorporating the cross-linker b(PIM)B-S in ultra-small colloidal SNS particles. In-situ incorporation of DOX molecules resulted in SPS-DOX. The pH-responsive SPS nanocomposites were tested as biocompatible nanocarriers for controllable doxorubicin (DOX) delivery. We conclude that SPS is a unique colloid which has promising potential for technological applications such as advanced drug delivery systems, wastewater remediation and as a catalyst for green organic reactions in water.
本文报道了一种具有海胆状结构的新型单分散胶体的工程设计，其中硅烷表面由芳香族有机交联剂桥接，作为载药纳米载体，如用于乳腺癌细胞的阿霉素（DOX）。虽然使用了树枝状纤维纳米硅（DFNS），但我们没有观察到树枝状结构，这些颗粒被称为海胆状纳米结构硅（SNS）。由于 SNS 的结构由许多从核心伸出的硅纳米纤维组成，类似于海胆的刺。对于芳香族结构的交联剂，使用了双（丙基亚氨基甲基）苯（b（PIM）B-S 或硅烷化对苯二甲醛），通过简单的席夫碱反应，由对苯二甲醛和 3-氨丙基三乙氧基硅烷（APTES）制备。b（PIM）B-S 桥在敞口容器回流条件下被引入 SNS 中。SPS 是指在超小胶体 SNS 颗粒中引入交联剂 b（PIM）B-S 后得到的产物。DOX 分子的原位掺入导致了 SPS-DOX 的形成。对 pH 响应的 SPS 纳米复合材料作为生物相容的纳米载体进行了测试，用于可控阿霉素（DOX）的递送。我们得出结论，SPS 是一种独特的胶体，具有在先进药物传递系统、废水修复以及作为水相绿色有机反应催化剂等方面有很大的应用潜力。
