Center of Expertise Urban Vitality, Faculty of Sports and Nutrition, Amsterdam University of Applied Sciences, Amsterdam, the Netherlands; Amsterdam Public Health, Aging and Later Life, Amsterdam, the Netherlands; Department of Nutrition and Dietetics, Amsterdam University Medical Centers, Amsterdam, the Netherlands.
Center of Expertise Urban Vitality, Faculty of Sports and Nutrition, Amsterdam University of Applied Sciences, Amsterdam, the Netherlands.
J Am Med Dir Assoc. 2023 Aug;24(8):1163-1172. doi: 10.1016/j.jamda.2023.05.017. Epub 2023 Jun 21.
This systematic review aims to reevaluate the role of minerals on muscle mass, muscle strength, physical performance, and the prevalence of sarcopenia in community-dwelling and institutionalized older adults.
Systematic review.
In March 2022, a systematic search was performed in PubMed, Scopus, and Web of Sciences using predefined search terms. Original studies on dietary mineral intake or mineral serum blood concentrations on muscle mass, muscle strength, and physical performance or the prevalence of sarcopenia in older adults (average age ≥65 years) were included.
Eligibility screening and data extraction was performed by 2 independent reviewers. Quality assessment was performed with the Effective Public Health Practice Project (EPHPP) Quality Assessment Tool for Quantitative Studies. Risk of bias was evaluated using the Risk Of Bias In Non-randomized Studies-of Exposure (ROBINS-E) tool.
From the 15,622 identified articles, a total of 45 studies were included in the review, mainly being cross-sectional and observational studies. Moderate quality of evidence showed that selenium (n = 8) and magnesium (n = 7) were significantly associated with muscle mass, strength, and physical performance as well as the prevalence of sarcopenia. For calcium and zinc, no association could be found. For potassium, iron, sodium, and phosphorus, the association with sarcopenic outcomes remains unclear as not enough studies could be included or were nonconclusive (low quality of evidence).
This systematic review shows a potential role for selenium and magnesium on the prevention and treatment of sarcopenia in older adults. More randomized controlled trials are warranted to determine the impact of minerals on sarcopenia in older adults.
本系统评价旨在重新评估矿物质对肌肉量、肌肉力量、身体机能以及社区居住和机构居住的老年人中肌少症患病率的作用。
系统评价。
2022 年 3 月，使用预定义的搜索词在 PubMed、Scopus 和 Web of Sciences 中进行了系统搜索。纳入了关于膳食矿物质摄入量或矿物质血清血浓度对老年人（平均年龄≥65 岁）肌肉量、肌肉力量和身体机能或肌少症患病率影响的原始研究。
由 2 名独立评审员进行资格筛选和数据提取。使用有效公共卫生实践项目（EPHPP）定量研究质量评估工具进行质量评估。使用非随机暴露研究的偏倚风险（ROBINS-E）工具评估偏倚风险。
从 15622 篇鉴定的文章中，共有 45 项研究被纳入综述，主要是横断面和观察性研究。中等质量的证据表明，硒（n=8）和镁（n=7）与肌肉量、力量和身体机能以及肌少症的患病率显著相关。对于钙和锌，没有发现关联。对于钾、铁、钠和磷，与肌少症结果的关联尚不清楚，因为纳入的研究不足或结果不确定（低质量证据）。
本系统评价表明，硒和镁在预防和治疗老年人肌少症方面具有潜在作用。需要更多的随机对照试验来确定矿物质对老年人肌少症的影响。
