Mitsuhata N, Seki M, Matsumura Y, Ohmori H
J Urol. 1986 Sep;136(3):580-5. doi: 10.1016/s0022-5347(17)44978-0.
A combination of 50 to 80 mg. per m.2 cis-platinum and 30 to 50 mg. per m.2 doxorubicin or 30 to 50 mg. per m.2 tetrahydropyranyl-doxorubicin instead of doxorubicin was infused into the bilateral internal iliac artery for the treatment of 20 patients with T3 or T4 advanced bladder cancer. Angiotensin II was administered together with these chemotherapeutic agents by means of an infusion pump at a rate of 1.5 to 2.0 micrograms. per minute for 20 minutes for both sides. Among the 20 patients complete (9) and partial (8) responses were obtained after only 1 or 2 courses of this intra-arterial treatment. Histological examination showed severe tumor destruction with no viable cells in 6 and no tumor in 4 of the 15 evaluable cases. Selective enhancement of regional blood flow in the tumor region after intra-arterial infusion of angiotensin II was observed by continuous target arterial 81mkrypton infusion. Intra-arterial chemotherapy with combined angiotensin II may be clinically useful for treatment of primary or metastatic bladder carcinoma.
将每平方米50至80毫克的顺铂与每平方米30至50毫克的阿霉素或每平方米30至50毫克的四氢吡喃基阿霉素（代替阿霉素）联合，经双侧髂内动脉注入，用于治疗20例T3或T4期晚期膀胱癌患者。血管紧张素II与这些化疗药物一起通过输液泵以每分钟1.5至2.0微克的速率给药，双侧均给药20分钟。在这20例患者中，仅经过1或2个疗程的这种动脉内治疗后，就获得了完全缓解（9例）和部分缓解（8例）。组织学检查显示，在15例可评估病例中，6例肿瘤严重破坏，无存活细胞，4例无肿瘤。通过连续靶动脉注入81氪，观察到动脉内注入血管紧张素II后肿瘤区域局部血流的选择性增强。联合血管紧张素II的动脉内化疗在临床上可能对原发性或转移性膀胱癌的治疗有用。
