基于甲状腺癌性别二态性和基因表达改变特征对肿瘤抑制基因和癌基因的综合分析
An integrative analysis of the tumor suppressors and oncogenes from sexual dimorphism and gene expression alteration features in thyroid cancer.
作者信息
Huang Yue, Wang Yaoxin, Liu Sining, Xu Zhengmin, Chen Wen-Xia
机构信息
Department of Otolaryngology-Head and Neck Surgery, Children's Hospital of Fudan University, Shanghai, China.
Department of Laboratory Medicine, Wu Song Branch, Zhongshan Hospital, Fudan University, Shanghai, China.
出版信息
Cancer Biomark. 2023;38(1):1-16. doi: 10.3233/CBM-230029.
BACKGROUND
The incidence of thyroid cancer has risen rapidly over the last decades. Although mortality rates are relatively low compared to other cancers, the rate of new cases started to increase in the early 2000s. While tumor suppressors and oncogenes were recently identified in thyroid cancer, the potential roles of these genes in thyroid cancer remain unclear.
OBJECTIVE
Analyze the roles and functions of tumor suppressors and oncogenes in thyroid cancer.
METHODS
Thyroid cancer data were collected from public databases, such as the UCSC Xena database of TCGA thyroid cancer, TISIDB, and UALCAN. The genes frequently associated with unfavorable thyroid cancer were examined and validated. The association of these target genes with thyroid tumorigenesis, stages, subtypes, and survival rates were analyzed. Additionally, the genes aberrantly expressed in thyroid cancer and significantly involved in thyroid tumorigenesis, stages, subtypes, and survival rates were identified.
RESULTS
Female sex was identified as a risk factor for thyroid cancer. The expression of PAPSS2, PDLIM3, COPZ2, ALDH1B1, ANTXR1, GUF1, and SENP6 negatively correlated with thyroid cancer prognosis.
CONCLUSION
Female sex was a risk factor for thyroid cancer. In addition, our analysis suggested that PAPSS2, PDLIM3, COPZ2, ALDH1B1, ANTXR1, GUF1, and SENP6 are negatively correlated with the prognosis of thyroid cancer. The expression of ANTXR1, GUF1, and PDLIM3 was weakly associated with thyroid cancer's immune and molecular subtypes.
背景
在过去几十年中，甲状腺癌的发病率迅速上升。尽管与其他癌症相比，其死亡率相对较低，但新发病例数在21世纪初开始增加。虽然最近在甲状腺癌中发现了肿瘤抑制基因和癌基因，但这些基因在甲状腺癌中的潜在作用仍不清楚。
目的
分析肿瘤抑制基因和癌基因在甲状腺癌中的作用和功能。
方法
从公共数据库收集甲状腺癌数据，如TCGA甲状腺癌的UCSC Xena数据库、TISIDB和UALCAN。检查并验证与不良甲状腺癌频繁相关的基因。分析这些靶基因与甲状腺肿瘤发生、分期、亚型和生存率的关联。此外，鉴定在甲状腺癌中异常表达并显著参与甲状腺肿瘤发生、分期、亚型和生存率的基因。
结果
女性被确定为甲状腺癌的一个危险因素。PAPSS2、PDLIM3、COPZ2、ALDH1B1、ANTXR1、GUF1和SENP6的表达与甲状腺癌预后呈负相关。
结论
女性是甲状腺癌的一个危险因素。此外，我们的分析表明，PAPSS2、PDLIM3、COPZ2、ALDH1B1、ANTXR1、GUF1和SENP6与甲状腺癌的预后呈负相关。ANTXR1、GUF1和PDLIM3的表达与甲状腺癌的免疫和分子亚型弱相关。
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