Sirotko M L, Denisenko M B, Zolotovskaya I A, Komarova M V
Samara State Medical University, 89 Chapaevskaya str., Samara 443099, Russian Federation, e-mail:
National Research University «Higher School of Economics», 11 Pokrovsky Boulevard, Moscow 109028, Russian Federation.
Adv Gerontol. 2023;36(2):198-205.
An important area of medical and social research is prospective studies of a cohort of older patients with chronic non-communicable diseases aimed at studying the level of mortality, taking into account the presence/absence of senile asthenia syndrome. A prospective clinical and epidemiological study was conducted on 1 261 people aged 80 years and older receiving medical care on an outpatient basis. Three groups of patients were formed: without senile asthenia syndrome (7,6%), in a state of pre-asthenia (23,5%), with senile asthenia (68,9%). After a calendar year, an analysis was made of the causes of death of respondents in all three groups. A high statistically significant incidence of chronic diseases in patients with senile asthenia syndrome compared with those without signs of this syndrome was noted in arterial hypertension, chronic heart failure, osteoarthritis, age-related macular degeneration, chronic kidney disease, dementia, cancer, anemia, uncomplicated diabetes mellitus. In the structure of causes of death in patients aged 80 years and older, diseases of the circulatory system, nervous system, neoplasms, liver diseases, and diabetes mellitus predominated. The odds ratio of the risk of dying within a year in patients without frailty syndrome is 0,32 (compared to patients with frailty, in which the risk is taken as 1).
医学和社会研究的一个重要领域是对一组患有慢性非传染性疾病的老年患者进行前瞻性研究，旨在考虑老年衰弱综合征的有无来研究死亡率水平。对1261名80岁及以上接受门诊医疗护理的人群进行了一项前瞻性临床和流行病学研究。将患者分为三组：无老年衰弱综合征组（7.6%）、衰弱前期组（23.5%）、老年衰弱组（68.9%）。经过一个日历年，对所有三组受访者的死亡原因进行了分析。与无该综合征体征的患者相比，老年衰弱综合征患者中慢性病的统计学显著高发病率见于动脉高血压、慢性心力衰竭、骨关节炎、年龄相关性黄斑变性、慢性肾病、痴呆、癌症、贫血、非复杂性糖尿病。在80岁及以上患者的死亡原因结构中，循环系统疾病、神经系统疾病、肿瘤、肝脏疾病和糖尿病占主导。无衰弱综合征患者一年内死亡风险的优势比为0.32（与衰弱患者相比，后者风险设为1）。
