一项关于急性淋巴细胞白血病患者外周和中枢听觉通路的纵向研究。
A longitudinal study of the peripheral and central auditory pathways in individuals with acute lymphoid leukemia.
机构信息
Department of Physical Therapy, Speech-language Pathology and Audiology, and Occupational Therapy, Faculdade de Medicina (FMUSP), Universidade de São Paulo, São Paulo, SP, Brazil.
Department of Physical Therapy, Speech-language Pathology and Audiology, and Occupational Therapy, Faculdade de Medicina (FMUSP), Universidade de São Paulo, São Paulo, SP, Brazil.
出版信息
Clinics (Sao Paulo). 2023 Jun 23;78:100234. doi: 10.1016/j.clinsp.2023.100234. eCollection 2023.
OBJECTIVE
To characterize the peripheral and central auditory pathways in individuals with Acute Lymphoid Leukemia (ALL) and compare assessment results before and during chemotherapy.
METHOD
The study included 17 subjects with ALL, divided into two age groups: 3 to 6 (11 individuals) and 7 to 16 years old (6 individuals). Each subject was evaluated twice (before and 3 to 6 months after chemotherapy treatment) with the following procedures: medical history survey, otoscopy, Pure-Tone Threshold (PTA) and speech audiometry, acoustic immittance measures, Brainstem Auditory Evoked Potentials (BAEP) and Long-Latency Auditory Evoked Potentials (LLAEP).
RESULTS
PTA was normal. Tympanometry was abnormal in the second assessment in 2 individuals aged 3 to 6 years. One subject in each age group had absent ipsilateral acoustic reflexes. In high-frequency audiometry, 1 individual had abnormal results. BAEP was abnormal in 5 (first assessment) and 7 individuals (second assessment) aged 3 to 6 years and 2 (first assessment) and 1 individual (second assessment) aged 7 to 16 years. As for LLAEP, P1 latency was increased in 5 (first assessment) and 7 individuals (second assessment) aged 3 to 6 years.
CONCLUSION
No hearing loss was identified in the behavioral audiological assessment. BAEP was more affected in the 3-to-6-year-old group, with greater impairment in the lower brainstem in the first and second assessments. In LLAEP, P1 was the most impaired component in children aged 3 to 6 years, and P2 and N2 were so for those 7 to 16 years old, especially in the second assessment.
目的
描述急性淋巴细胞白血病（ALL）患者的外周和中枢听觉通路，并比较化疗前后的评估结果。
方法
本研究纳入了 17 名 ALL 患者，分为两个年龄组：3 至 6 岁（11 名）和 7 至 16 岁（6 名）。每位患者均接受了两次评估（化疗前和化疗后 3 至 6 个月），评估内容包括：病史调查、耳镜检查、纯音听阈（PTA）和言语测听、声导抗测试、脑干听觉诱发电位（BAEP）和长潜伏期听觉诱发电位（LLAEP）。
结果
PTA 正常。在第二次评估中，2 名 3 至 6 岁的患者鼓室图异常。每个年龄组均有 1 名受试者对侧声反射缺失。在高频测听中，1 名患者结果异常。3 至 6 岁年龄组中有 5 名（第一次评估）和 7 名（第二次评估）受试者，7 至 16 岁年龄组中有 2 名（第一次评估）和 1 名（第二次评估）受试者的 BAEP 异常。LLAEP 方面，5 名（第一次评估）和 7 名（第二次评估）3 至 6 岁患者的 P1 潜伏期延长。
结论
行为听力学评估未发现听力损失。BAEP 在 3 至 6 岁年龄组中受影响更大，第一次和第二次评估中较低脑干的损伤更为严重。LLAEP 中，3 至 6 岁儿童受损最严重的是 P1 成分，7 至 16 岁儿童受损最严重的是 P2 和 N2，尤其是第二次评估。
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