da Silva Aline Medeiros, Latorre Maria do Rosário Dias de Oliveira, Cristofani Lilian Maria, Odone Filho Vicente
USP Schoolo Public Health, University of São Paulo.
Braz J Otorhinolaryngol. 2007 Sep-Oct;73(5):608-14. doi: 10.1016/s1808-8694(15)30120-8.
The treatment of cancer in children has several side effects, including ototoxicity. Inner ear structures may be affected and hearing loss may ensue.
To estimate the prevalence of hearing loss in patients with cancer using the American Speech-Language-Hearing Association (ASHA), the Pediatric Oncology Group Toxicity (POGT), and the Bilateral Hearing Loss (PAB) criteria.
a prospective study.
94 patients admitted between 2003 and 2004 were analyzed. Visual inspection of the external auditory meatus and an audiologic evaluation were done. Descriptive statistics was used to characterize the sample, and Kappa statistics was used to investigate concordance of hearing loss in the three types of classification.
The prevalence of hearing loss was 42.5% using ASHA, 40.4% using POGT, and 12.8% using PAB. The concordance of hearing loss was weak for POGT and PAB (k=0.36) and for PAB and ASHA (k=0.33). The concordance between ASHA and POGT was almost perfect (k=0.96).
Hearing loss is an important side effect of the treatment of cancer in children. Periodic audiology monitoring is recommended to detect early hearing loss and to revise the treatment if necessary. Adoption of a classification system that detects mild hearing loss (ASHA) is recommended.
儿童癌症治疗有多种副作用，包括耳毒性。内耳结构可能受到影响，进而可能导致听力丧失。
使用美国言语语言听力协会（ASHA）、儿科肿瘤学组毒性（POGT）和双侧听力丧失（PAB）标准评估癌症患者听力丧失的患病率。
一项前瞻性研究。
分析了2003年至2004年期间收治的94例患者。对外耳道进行了目视检查并进行了听力评估。使用描述性统计来描述样本特征，并使用Kappa统计来研究三种分类中听力丧失的一致性。
使用ASHA标准时听力丧失的患病率为42.5%，使用POGT标准时为40.4%，使用PAB标准时为12.8%。POGT与PAB之间（k = 0.36）以及PAB与ASHA之间（k = 0.33）听力丧失的一致性较弱。ASHA与POGT之间的一致性几乎完美（k = 0.96）。
听力丧失是儿童癌症治疗的一个重要副作用。建议定期进行听力监测，以早期发现听力丧失并在必要时调整治疗方案。建议采用能检测轻度听力丧失的分类系统（ASHA）。
