School of Chemical Engineering, University of Campinas, Av. Albert Einstein, 500, Campinas, São Paulo, Brazil.
School of Chemical Engineering, University of Campinas, Av. Albert Einstein, 500, Campinas, São Paulo, Brazil.
Environ Res. 2023 Sep 15;233:116503. doi: 10.1016/j.envres.2023.116503. Epub 2023 Jun 24.
This paper investigated the uptake of CIP and OFL in single and multicomponent adsorptive systems using modified carbon nanotubes (CNTs) as adsorbent material. The characterization analyses of the pre- and post-process material by XPS, TG/DTG, FT-IR, SEM/EDS, and XRD helped in the elucidation of the mechanisms, indicating greater involvement of n-n and π -π interactions. In the kinetic studies, the simple systems with CIP and OFL were similar, both showed equilibrium time around 20/30 min and increased adsorptive capacity with increasing initial drug concentration. In the multicomponent system, different fractions of CIP and OFL were tested and the time to reach equilibrium also varied between 20 and 30 min. In general, the adsorption capacity of CIP is slightly lower than that of OFL under the conditions tested. The selectivity analysis of the system showed that the selectivity's of the two drugs are identical in equimolar fractions. The mathematical modeling of the kinetic data indicated that in monocomponent systems, the model of pseudo-second order (PSO) adequately described both CIP and OFL kinetics. Furthermore, with the implementation of Artificial Neural Networks (ANN), it was possible to obtain a more assertive prediction of the behavior of single and binary systems.
本研究采用改性碳纳米管（CNT）作为吸附材料，考察了在单组分和多组分吸附体系中 CIP 和 OFL 的吸附情况。通过 XPS、TG/DTG、FT-IR、SEM/EDS 和 XRD 对预处理和后处理材料进行的表征分析有助于阐明吸附机制，表明 n-n 和 π-π 相互作用的参与度更大。在动力学研究中，CIP 和 OFL 的简单体系相似，两者均在 20/30 分钟左右达到平衡时间，并且随着初始药物浓度的增加而增加吸附能力。在多组分体系中，测试了 CIP 和 OFL 的不同分数，达到平衡的时间也在 20 到 30 分钟之间变化。一般来说，在测试条件下，CIP 的吸附能力略低于 OFL。该体系的选择性分析表明，两种药物在等摩尔分数下的选择性相同。对动力学数据的数学模型表明，在单组分体系中，拟二级动力学模型（PSO）可以很好地描述 CIP 和 OFL 的动力学。此外，通过人工神经网络（ANN）的实施，可以更有把握地预测单组分和双组分体系的行为。
