Morita Y, Koyama K
Jpn J Pharmacol. 1979 Feb;29(1):59-65. doi: 10.1254/jjp.29.59.
Concentration of adrenocorticotropic hormone (ACTH) in the serum increased and reached the maximum level 10 min after the injection of histamine (dihydrochloride, 0.5 or 1 mg/100 g) i.p. into rats. The maximum concentration of ACTH in the serum was dependent on the dose of histamine. The ACTH concentration then decreased and was close to the normal level 30 to 60 min after the injection. The ACTH secretion induced by histamine (0.5 mg/100 g) was inhibited completely by the pretreatment with the antagonists of H1-receptor, diphenyhydramine (hydrochloride, 0.2--0.5 mg/100 g), promethazine (hydrochloride, 0.1--0.2 mg/100 g) and d-chlorpheniramine (maleate, 0.02--0.05 mg/100 g). The antagonist of H2-receptor, metiamide (2--4 mg/100 g) inhibited the ACTH secretion significantly but not completely. These results suggest that H1-receptor plays a major role in the histamine-induced ACTH secretion, although H2-receptor is also involved in this ACTH secretion.
给大鼠腹腔注射组胺（二盐酸盐，0.5或1毫克/100克）后，血清中促肾上腺皮质激素（ACTH）的浓度升高，并在注射后10分钟达到最高水平。血清中ACTH的最高浓度取决于组胺的剂量。然后ACTH浓度下降，并在注射后30至60分钟接近正常水平。组胺（0.5毫克/100克）诱导的ACTH分泌被H1受体拮抗剂苯海拉明（盐酸盐，0.2 - 0.5毫克/100克）、异丙嗪（盐酸盐，0.1 - 0.2毫克/100克）和氯苯那敏（马来酸盐，0.02 - 0.05毫克/100克）预处理完全抑制。H2受体拮抗剂甲硫米特（2 - 4毫克/100克）显著但未完全抑制ACTH分泌。这些结果表明，H1受体在组胺诱导的ACTH分泌中起主要作用，尽管H2受体也参与了这种ACTH分泌。
