载脂蛋白 E 在脂质代谢和神经退行性疾病中的作用。
Apolipoprotein E in lipid metabolism and neurodegenerative disease.
机构信息
Genetics and Biochemistry Branch, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), National Institutes of Health, Bethesda, MD, USA.
Genetics and Biochemistry Branch, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), National Institutes of Health, Bethesda, MD, USA.; National Institute of Neurological Disorders and Stroke (NINDS), National Institutes of Health, Bethesda, MD, USA; Center for Alzheimer's and Related Dementias (CARD), National Institutes of Health, Bethesda, MD, USA.
出版信息
Trends Endocrinol Metab. 2023 Aug;34(8):430-445. doi: 10.1016/j.tem.2023.05.002. Epub 2023 Jun 24.
Dysregulation of lipid metabolism has emerged as a central component of many neurodegenerative diseases. Variants of the lipid transport protein, apolipoprotein E (APOE), modulate risk and resilience in several neurodegenerative diseases including late-onset Alzheimer's disease (LOAD). Allelic variants of the gene, APOE, alter the lipid metabolism of cells and tissues and have been broadly associated with several other cellular and systemic phenotypes. Targeting APOE-associated metabolic pathways may offer opportunities to alter disease-related phenotypes and consequently, attenuate disease risk and impart resilience to multiple neurodegenerative diseases. We review the molecular, cellular, and tissue-level alterations to lipid metabolism that arise from different APOE isoforms. These changes in lipid metabolism could help to elucidate disease mechanisms and tune neurodegenerative disease risk and resilience.
脂质代谢失调已成为许多神经退行性疾病的核心组成部分。脂质转运蛋白载脂蛋白 E（APOE）的变体可调节包括晚发性阿尔茨海默病（LOAD）在内的几种神经退行性疾病的风险和恢复能力。APOE 基因的等位变体改变了细胞和组织的脂质代谢，并与其他几种细胞和全身表型广泛相关。针对 APOE 相关代谢途径可能为改变与疾病相关的表型提供机会，并因此减轻多种神经退行性疾病的疾病风险和恢复能力。我们综述了不同 APOE 同种型引起的脂质代谢的分子、细胞和组织水平的改变。这些脂质代谢的变化有助于阐明疾病机制，并调整神经退行性疾病的风险和恢复能力。
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