FSP1：铁死亡的关键调节因子。
FSP1: a key regulator of ferroptosis.
机构信息
Department of Otolaryngology Head and Neck Surgery, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China; Research Center of Carcinogenesis and Targeted Therapy, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China; National Clinical Research Center of Geriatric Disorders, Xiangya Hospital of Central South University, Changsha, Hunan 410008, China; Cancer Research Institute, Basic School of Medicine, Central South University, Changsha, Hunan 410011, China.
Cancer Research Institute, Basic School of Medicine, Central South University, Changsha, Hunan 410011, China.
出版信息
Trends Mol Med. 2023 Sep;29(9):753-764. doi: 10.1016/j.molmed.2023.05.013. Epub 2023 Jun 23.
Ferroptosis suppressor protein 1 (FSP1) is one of the main regulatory molecules of ferroptosis. FSP1 functions through the FSP1-coenzyme Q10 (CoQ10)-NAD(P)H axis and the vitamin K redox cycle. FSP1 is regulated by upstream factors, including transcription factors and noncoding RNA (ncRNA), and is subject to epigenetic modifications, which affect the progress of FSP1-related diseases. FSP1 is closely associated with the poor prognosis of malignant tumors and plays an important role in disease treatment. This review aims to provide a comprehensive understanding of the role of FSP1 in ferroptosis regulation by summarizing regulatory pathways, possible mechanisms involving FSP1, and the relationship between FSP1 and disease prognosis and treatment.
铁死亡抑制蛋白 1（FSP1）是铁死亡的主要调节分子之一。FSP1 通过 FSP1-辅酶 Q10（CoQ10）-NAD（P）H 轴和维生素 K 氧化还原循环发挥作用。FSP1 受上游因素的调节，包括转录因子和非编码 RNA（ncRNA），并受到表观遗传修饰的影响，这影响了与 FSP1 相关的疾病的进展。FSP1 与恶性肿瘤的不良预后密切相关，在疾病治疗中发挥重要作用。本综述通过总结 FSP1 的调节途径、可能涉及 FSP1 的机制以及 FSP1 与疾病预后和治疗的关系，旨在提供对 FSP1 在铁死亡调节中的作用的全面理解。
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