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混合精油和洗必泰对牙周病致病菌的抗菌效果(-一项体外研究。

Antimicrobial Efficacy of Blended Essential Oil and Chlorhexidine against Periodontal Pathogen ()-An Study.

机构信息

Department of Periodontology, SRM Kattankulathur Dental College and Hospital, SRM Institute of Science and Technology, SRM Nagar, Kattankulathur 603203, Kancheepuram, Tamil Nadu, India.

Department of Preventive Dentistry, College of Dentistry, Jazan University, Saudi Arabia.

出版信息

Niger J Clin Pract. 2023 May;26(5):625-629. doi: 10.4103/njcp.njcp_787_22.

Abstract

BACKGROUND

Essential oils (EOs) have a considerable amount of therapeutic and preventive effect in treating dental diseases due to their wider potential as antibacterial and anti-inflammatory agents. EOs like virgin coconut oil, eucalyptus oil, peppermint oil thyme oil, and clove oil, when used in combination, may further have enhanced antimicrobial effects. However, limited information exists on the synergistic effect of these oils when used in combination, especially on the primary periodontal pathogen Porphyromonas gingivalis.

AIM

The current study aims to compare the antimicrobial efficacy of commercially available EO on the periodontal pathogen, P. gingivalis, in comparison to chlorhexidine (CHX).

MATERIALS AND METHODS

Antimicrobial efficacy of EO and CHX was assessed at various concentrations against the periodontal pathogen P. gingivalis, by evaluating the minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC).

RESULTS

P. gingivalis was seen to be sensitive at a MIC of 100 μg/ml and 50 μg/ml concentration of the EO, which is regarded as the MIC of EO against P. gingivalis and CHX effectively inhibited microbial growth at 0.4 μg/ml.

CONCLUSION

A combination of EOs possesses a potent antibacterial activity against P. gingivalis, and the antibacterial efficacy increases with increasing concentration of EOs.

摘要

背景

由于其作为抗菌和抗炎剂的广泛潜力,精油 (EO) 在治疗口腔疾病方面具有相当大的治疗和预防作用。当将 virgin coconut oil、桉树油、薄荷油、百里香油和丁香油等精油组合使用时,可能会进一步增强抗菌效果。然而,关于这些油组合使用时的协同作用的信息有限,特别是在原发性牙周病病原体牙龈卟啉单胞菌上。

目的

本研究旨在比较市售 EO 对牙周病病原体牙龈卟啉单胞菌的抗菌功效,与洗必泰 (CHX) 进行比较。

材料和方法

通过评估最小抑菌浓度 (MIC) 和最小杀菌浓度 (MBC),评估 EO 和 CHX 在不同浓度下对牙周病病原体 P. gingivalis 的抗菌功效。

结果

P. gingivalis 在 100μg/ml 和 50μg/ml 的 EO 浓度下表现出敏感性,这被认为是 EO 对 P. gingivalis 的 MIC,而 CHX 则能有效抑制微生物生长,其 MIC 为 0.4μg/ml。

结论

EO 的组合对 P. gingivalis 具有强大的抗菌活性,抗菌功效随 EO 浓度的增加而增加。

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