血管紧张素受体-脑啡肽酶抑制剂在临床糖尿病管理中的影响：潜在的益处和陷阱。
Impact of the angiotensin receptor-neprilysin inhibitor in clinical diabetes management: Potential benefits and pitfalls.
机构信息
Department of Diabetes, Endocrinology and Nutrition, Kyoto University Graduate School of Medicine, Kyoto, Japan.
Department of Diabetes, Endocrinology and Metabolism, Gifu University Graduate School of Medicine, Gifu, Japan.
出版信息
J Diabetes Investig. 2023 Sep;14(9):1038-1040. doi: 10.1111/jdi.14044. Epub 2023 Jun 25.
Abstract
The possible mechanism of increased urinary C-peptide due to neprilysin inhibitors is investigated. Neprilysin inhibition blocks degradation of natriuretic peptides, and elicits a natriuretic and antihypertensive effect. Neprilysin inhibition might similarly block degradation of C-peptides in the kidney and thus increase the urinary C-peptide level.
摘要
正在研究肾素抑制剂导致尿 C 肽增加的可能机制。肾素抑制剂可阻止利钠肽的降解，并产生利钠和降压作用。肾素抑制剂可能同样阻止肾脏中 C 肽的降解，从而增加尿 C 肽水平。
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