Department of Oral and Maxillofacial Radiology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences.
Radiological Technology, Graduate School of Health Sciences, Okayama University.
Acta Med Okayama. 2023 Jun;77(3):273-280. doi: 10.18926/AMO/65492.
Diffusion kurtosis (DK) imaging (DKI), a type of restricted diffusion-weighted imaging, has been reported to be useful for tumor diagnoses in clinical studies. We developed a software program to simultaneously create DK images with apparent diffusion coefficient (ADC) maps and conducted an initial clinical study. Multi-shot echo-planar diffusion-weighted images were obtained at b-values of 0, 400, and 800 sec/mm2 for simple DKI, and DK images were created simultaneously with the ADC map. The usefulness of the DK image and ADC map was evaluated using a pixel analysis of all pixels and a median analysis of the pixels of each case. Tumor and normal tissues differed significantly in both pixel and median analyses. In the pixel analysis, the area under the curve was 0.64 for the mean kurtosis (MK) value and 0.77 for the ADC value. In the median analysis, the MK value was 0.74, and the ADC value was 0.75. The MK and ADC values correlated moderately in the pixel analysis and strongly in the median analysis. Our simple DKI system created DK images simultaneously with ADC maps, and the obtained MK and ADC values were useful for differentiating head and neck tumors from normal tissue.
扩散峰度（DK）成像（DKI）是一种受限扩散加权成像，已在临床研究中被报道对肿瘤诊断有用。我们开发了一个软件程序，可以同时创建具有表观扩散系数（ADC）图的 DK 图像，并进行了初步的临床研究。在 b 值为 0、400 和 800 sec/mm2 的情况下，进行多 shot 回波平面扩散加权成像以进行简单的 DKI，同时创建 DK 图像和 ADC 图。使用所有像素的像素分析和每个病例的像素中位数分析评估 DK 图像和 ADC 图的有用性。肿瘤和正常组织在像素和中位数分析中均有显著差异。在像素分析中，平均峰度（MK）值的曲线下面积为 0.64，ADC 值为 0.77。在中位数分析中，MK 值为 0.74，ADC 值为 0.75。MK 和 ADC 值在像素分析中呈中度相关，在中位数分析中呈强相关。我们的简单 DKI 系统可以同时创建具有 ADC 图的 DK 图像，并且获得的 MK 和 ADC 值可用于区分头颈部肿瘤与正常组织。
