Orabona Rossana, Corda Luciano, Giordani Jordan, Bernardi Matteo, Maggi Claudia, Mazzoni Giorgia, Pedroni Leonardo, Uccelli Silvia, Zatti Sonia, Sartori Enrico, Zanardini Cristina
Obstetrics and Gynecology Unit, ASST Spedali Civili, Brescia, Italy.
Respiratory Medicine Unit, ASST Spedali Civili, Brescia, Italy.
Int J Gynaecol Obstet. 2024 Jan;164(1):140-147. doi: 10.1002/ijgo.14967. Epub 2023 Jun 26.
To investigate pathological associations between sleep-disordered breathing (SDB) and pregnancy outcomes.
From May 2016 to September 2019, obese women during their uncomplicated singleton pregnancies underwent screening sleep questionnaires, oxygen saturation monitoring, and, in proper cases, complete overnight polysomnography. Their medical records were also recorded.
In all, 112 pregnant women were included in the study cohort; 44 showed an oxygen desaturation index ≥10, and their newborns had a significantly higher rate of congenital abnormalities and respiratory distress syndrome compared with the women with normal pulse oximetry. Stepwise multivariate regression analysis showed that basal oxygen saturation was independently associated with the occurrence of fetal growth restriction.
Among obese pregnant women, the rate of congenital abnormalities is higher in the ones with altered pulse oximetry. Maternal basal oxygen saturation in the first trimester of pregnancy predicts fetal growth restriction independently of maternal age, ethnicity, body mass index, gravidity, and hypertensive disorders of pregnancy.
探讨睡眠呼吸障碍（SDB）与妊娠结局之间的病理关联。
2016年5月至2019年9月，对单胎妊娠且无并发症的肥胖女性进行睡眠问卷调查、血氧饱和度监测，必要时进行整夜多导睡眠图监测，并记录她们的病历。
本研究队列共纳入112名孕妇；44名孕妇的氧饱和度下降指数≥10，与脉搏血氧饱和度正常的孕妇相比，她们的新生儿先天性异常和呼吸窘迫综合征的发生率显著更高。逐步多因素回归分析显示基础血氧饱和度与胎儿生长受限的发生独立相关。
在肥胖孕妇中，脉搏血氧饱和度改变者的先天性异常发生率较高。妊娠早期孕妇的基础血氧饱和度可独立于孕妇年龄、种族、体重指数、妊娠次数和妊娠高血压疾病预测胎儿生长受限。
