Takeda Y, Kamiya Y, Honda K, Takano Y, Kamiya H
Jpn J Pharmacol. 1986 Apr;40(4):569-75. doi: 10.1254/jjp.40.569.
This report deals with the effect of cholecystokinin octapeptide (CCK-8) on the regulation of the behavior stimulated by dopaminergic drugs. Bilateral injection of CCK-8 (1 microgram per side) into the nucleus caudatus significantly reduced the locomotor hyperactivity induced by methamphetamine. Stereotyped sniffing and yawning occurred after intrastriatal administration of apomorphine (20 micrograms per side). Injections of CCK-8 into the nucleus caudatus completely inhibited the sniffing, but did not affect the yawning induced by apomorphine. It also had no effect on the basal dopamine (DA) level or the methamphetamine-induced DA level in the striatum. These results suggest that the injection of CCK-8 into the nucleus caudatus selectively inhibited the function of the dopaminergic system in the striatum, and blocked post-synaptic DA receptors.
本报告探讨了八肽胆囊收缩素（CCK-8）对多巴胺能药物刺激行为调节的影响。向尾状核双侧注射CCK-8（每侧1微克）可显著降低甲基苯丙胺诱导的运动性多动。纹状体内注射阿扑吗啡（每侧20微克）后出现刻板的嗅探和打哈欠行为。向尾状核注射CCK-8可完全抑制嗅探行为，但不影响阿扑吗啡诱导的打哈欠行为。它对纹状体内的基础多巴胺（DA）水平或甲基苯丙胺诱导的DA水平也没有影响。这些结果表明，向尾状核注射CCK-8可选择性抑制纹状体内多巴胺能系统的功能，并阻断突触后DA受体。
