Department of Child Neurology and Psychiatry, IRCCS Mondino Foundation, Pavia, Italy.
Department of Brain and Behavioral Sciences, University of Pavia, Pavia, Italy.
Epileptic Disord. 2023 Apr;25(2):160-172. doi: 10.1002/epd2.20003. Epub 2023 May 4.
This study aimed to describe the intellectual profile based on the Wechsler Intelligence Scale for Children 4th edition (WISC-IV) in children with self-limited epilepsy with centrotemporal spikes (SeLECTS), with an attempt to define possible predictive epilepsy-related variables of cognitive performance.
The WISC-IV was assessed in 161 children with SeLECTS and their cognitive profiles were compared to a matched sample of healthy control children.
Children with SeLECTS performed within normal range across all indices, demonstrating particular strength based on the Perceptual Reasoning Index. Compared to healthy control children, we observed a significant difference in performance based on the Full Scale Intelligence Quotient, Verbal Comprehension Index and Processing Speed Index. Regarding epilepsy-related variables, earlier onset of epilepsy, use of anti-seizure medications, the presence of neurodevelopmental disorders, a higher frequency of seizures, and a longer treatment duration were associated with an overall lower level of performance.
Children with SeLECTS performed within the average range for cognitive assessment based on the WISC-IV, demonstrating that children had normal levels of global intelligence. However, compared to healthy control children, children with SeLECTS showed a slightly lower level of performance. Reasoning skills represented the relative strengths in children with SeLECTS. Predictors of intellectual performance in patients with SeLECTS include epilepsy-related variables and neurodevelopmental comorbidities.
本研究旨在描述基于韦氏儿童智力量表第四版（WISC-IV）的智力特征，研究对象为具有局灶性有中央颞区棘波的儿童良性癫痫（SeLECTS）患儿，试图确定认知表现的可能与癫痫相关的预测变量。
对 161 例 SeLECTS 患儿进行 WISC-IV 评估，并将其认知特征与匹配的健康对照组儿童进行比较。
SeLECTS 患儿在所有指标上均处于正常范围内，基于知觉推理指数表现出特别的优势。与健康对照组儿童相比，我们观察到全量表智商、言语理解指数和加工速度指数方面的表现存在显著差异。就癫痫相关变量而言，癫痫发病年龄较早、使用抗癫痫药物、存在神经发育障碍、癫痫发作频率较高和治疗时间较长与整体表现水平较低相关。
SeLECTS 患儿在 WISC-IV 认知评估中表现处于平均范围内，表明患儿的整体智力水平正常。然而，与健康对照组儿童相比，SeLECTS 患儿的表现略低。推理技能是 SeLECTS 患儿的相对优势。SeLECTS 患儿智力表现的预测因素包括癫痫相关变量和神经发育合并症。
