Topoozian Mark, Calais Jeremie, Felker Ely, Sisk Anthony, Gonzalez Samantha, Lee Sean J, Marks Leonard S
Department of Urology, David Geffen School of Medicine at UCLA, United States.
Department of Nuclear Medicine, David Geffen School of Medicine at UCLA, United States.
Urol Case Rep. 2023 Jun 9;50:102461. doi: 10.1016/j.eucr.2023.102461. eCollection 2023 Sep.
Focal therapy of prostate cancer (PCa) is currently of great interest, but a metric of success. other than biopsy, is not yet available. In a patient with a repeatedly negative MRI and negative systematic biopsies, a scan employing the radioisotope Ga-PSMA-11 PET/CT identified a PSMA-avid hotspot in the prostate. PSMA-guided biopsy confirmed the diagnosis of a clinically-significant PCa. Following ablation of the lesion with high-intensity focused ultrasound (HIFU), the PSMA-avid lesion disappeared and targeted biopsy confirmed a fibrotic scar with no residual cancer. PSMA imaging may have a role in guiding diagnosis, focal ablation, and follow-up of men with PCa.
前列腺癌（PCa）的聚焦治疗目前备受关注，但除活检外，尚无成功的衡量标准。在一名MRI反复阴性且系统活检阴性的患者中，使用放射性同位素镓-PSMA-11 PET/CT进行的扫描在前列腺中发现了一个PSMA摄取热点。PSMA引导下的活检证实了临床意义重大的PCa诊断。在用高强度聚焦超声（HIFU）消融病变后，PSMA摄取病变消失，靶向活检证实为纤维化瘢痕，无残留癌症。PSMA成像可能在指导PCa男性患者的诊断、局部消融和随访中发挥作用。
