Singh Himanshu, Kumar Magesh, Kanungo Himanshu
Department of Oral and Maxillofacial Pathology and Oral Microbiology, Index Institute of Dental Sciences, Indore, Madhya Pradesh, India.
Department of Periodontics, Index Institute of Dental Sciences, Indore, Madhya Pradesh, India.
Glob Med Genet. 2023 Jun 23;10(2):123-128. doi: 10.1055/s-0043-1770768. eCollection 2023 Jun.
Acute myeloid leukemia (AML) is an immensely heterogeneous disease characterized by the clonal growth of promyelocytes or myeloblasts in bone marrow as well as in peripheral blood or tissue. Enhancement in the knowledge of the molecular biology of cancer and recognition of intermittent mutations in AML contribute to favorable circumstances to establish targeted therapies and enhance the clinical outcome. There is high interest in the development of therapies that target definitive abnormalities in AML while eradicating leukemia-initiating cells. In recent years, there has been a better knowledge of the molecular abnormalities that lead to the progression of AML, and the application of new methods in molecular biology techniques has increased that facilitating the advancement of investigational drugs. In this review, literature or information on various gene mutations for AML is discussed. English language articles were scrutinized in plentiful directories or databases like PubMed, Science Direct, Web of Sciences, Google Scholar, and Scopus. The important keywords used for searching databases is "Acute myeloid leukemia", "Gene mutation in Acute myeloid leukemia", "Genetic alteration in Acute myeloid leukemia," and "Genetic abnormalities in Acute myeloid leukemia."
急性髓系白血病（AML）是一种高度异质性疾病，其特征是骨髓以及外周血或组织中早幼粒细胞或原始粒细胞的克隆性增殖。癌症分子生物学知识的增强以及对AML中间歇性突变的认识为建立靶向治疗和改善临床结果创造了有利条件。开发针对AML明确异常同时根除白血病起始细胞的疗法备受关注。近年来，人们对导致AML进展的分子异常有了更深入的了解，分子生物学技术新方法的应用增加了这方面的认识，促进了研究性药物的发展。在这篇综述中，讨论了有关AML各种基因突变的文献或信息。在多个数据库或文献目录（如PubMed、Science Direct、Web of Sciences、Google Scholar和Scopus）中仔细查阅了英文文章。用于搜索数据库的重要关键词是“急性髓系白血病”、“急性髓系白血病中的基因突变”、“急性髓系白血病中的基因改变”以及“急性髓系白血病中的基因异常”。
