低促性腺激素性性腺功能减退的表观遗传学：严重急性呼吸综合征冠状病毒2与亲吻素之间的分子模拟
Epigenetics of Hypogonadotropic Hypogonadism: Molecular Mimicry between Severe Acute Respiratory Syndrome Coronavirus 2 and KISSR.
作者信息
Kanduc Darja
机构信息
Department of Biosciences, Biotechnologies and Biopharmaceutics, University of Bari, Bari, Italy.
出版信息
Glob Med Genet. 2023 Jun 23;10(2):129-132. doi: 10.1055/s-0043-1770767. eCollection 2023 Jun.
Abstract
This study analyzed KISS1 and its receptor KISSR for peptide sharing with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). It was found that SARS-CoV-2 shares numerous minimal immune pentapeptide determinants with KISSR only. The peptide sharing has a high immunologic potential since almost all the common peptides are present in 101 SARS-CoV-2-derived immunoreactive epitopes. Data are in favor of configuring molecular mimicry as an epigenetic factor that can alter KISSR thus causing the hypogonadotropic hypogonadism syndrome with which altered KISSR associates.
摘要
本研究分析了亲吻素1（KISS1）及其受体KISSR与严重急性呼吸综合征冠状病毒2（SARS-CoV-2）的肽段共享情况。研究发现，SARS-CoV-2仅与KISSR共享众多最小免疫五肽决定簇。这种肽段共享具有很高的免疫潜力，因为几乎所有常见肽段都存在于101个源自SARS-CoV-2的免疫反应性表位中。数据支持将分子模拟配置为一种表观遗传因素，它可以改变KISSR，从而导致与KISSR改变相关的低促性腺激素性性腺功能减退综合征。
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