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缺氧缺血性脑病研究问题的当前分析及未来治疗方式

Current analysis of hypoxic-ischemic encephalopathy research issues and future treatment modalities.

作者信息

She Hong-Qing, Sun Yi-Fei, Chen Li, Xiao Qiu-Xia, Luo Bo-Yan, Zhou Hong-Su, Zhou Di, Chang Quan-Yuan, Xiong Liu-Lin

机构信息

Department of Anesthesiology, Affiliated Hospital of Zunyi Medical University, Zunyi, China.

Translational Neurology Laboratory, Affiliated Hospital of Zunyi Medical University, Zunyi, China.

出版信息

Front Neurosci. 2023 Jun 9;17:1136500. doi: 10.3389/fnins.2023.1136500. eCollection 2023.

DOI:10.3389/fnins.2023.1136500
PMID:37360183
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10288156/
Abstract

Hypoxic-ischemic encephalopathy (HIE) is the leading cause of long-term neurological disability in neonates and adults. Through bibliometric analysis, we analyzed the current research on HIE in various countries, institutions, and authors. At the same time, we extensively summarized the animal HIE models and modeling methods. There are various opinions on the neuroprotective treatment of HIE, and the main therapy in clinical is therapeutic hypothermia, although its efficacy remains to be investigated. Therefore, in this study, we discussed the progress of neural circuits, injured brain tissue, and neural circuits-related technologies, providing new ideas for the treatment and prognosis management of HIE with the combination of neuroendocrine and neuroprotection.

摘要

缺氧缺血性脑病（HIE）是新生儿和成人长期神经功能障碍的主要原因。通过文献计量分析，我们分析了各国、各机构及作者对HIE的当前研究情况。同时，我们广泛总结了动物HIE模型及建模方法。关于HIE的神经保护治疗存在多种观点，临床主要治疗方法是治疗性低温，但其疗效仍有待研究。因此，在本研究中，我们探讨了神经回路、受损脑组织及神经回路相关技术的进展，为将神经内分泌与神经保护相结合的HIE治疗及预后管理提供新思路。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/da35/10288156/12139b9d2b69/fnins-17-1136500-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/da35/10288156/494938d6d0ed/fnins-17-1136500-g001.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/da35/10288156/ec071b7b80c1/fnins-17-1136500-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/da35/10288156/17bf48bddb6b/fnins-17-1136500-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/da35/10288156/988d3e915a25/fnins-17-1136500-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/da35/10288156/af31fbe27760/fnins-17-1136500-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/da35/10288156/12139b9d2b69/fnins-17-1136500-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/da35/10288156/494938d6d0ed/fnins-17-1136500-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/da35/10288156/43aad5a5b50a/fnins-17-1136500-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/da35/10288156/887759cb24eb/fnins-17-1136500-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/da35/10288156/414695bdb8a3/fnins-17-1136500-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/da35/10288156/ec071b7b80c1/fnins-17-1136500-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/da35/10288156/17bf48bddb6b/fnins-17-1136500-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/da35/10288156/988d3e915a25/fnins-17-1136500-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/da35/10288156/af31fbe27760/fnins-17-1136500-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/da35/10288156/12139b9d2b69/fnins-17-1136500-g009.jpg

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Structural and functional alterations within the Papez circuit in subacute stroke patients.
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