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植物糖原可提高白藜芦醇的溶解度和渗透性。

Phytoglycogen to Enhance the Solubility and Permeation of Resveratrol.

作者信息

Chen Jingfan, Yao Yuan

机构信息

Department of Food Science, Purdue University, 745 Agriculture Mall Drive, West Lafayette, IN 47907 United States.

出版信息

Food Biophys. 2023 Mar 31:1-10. doi: 10.1007/s11483-023-09785-8.

DOI:10.1007/s11483-023-09785-8
PMID:37362010
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10063939/
Abstract

This study investigated the capability of phytoglycogen (PG) to improve the water-soluble amount and bioavailability of resveratrol (RES). RES and PG were incorporated through co-solvent mixing and spray-drying to form PG-RES solid dispersions. The soluble amount of RES of PG-RES solid dispersions reached 289.6 μg/mL at PG:RES ratio of 50:1, compared with 45.6 μg/mL for RES alone. X-ray powder diffraction and Fourier-transform infrared spectroscopy tests suggested a significant reduction of RES crystallinity in PG-RES solid dispersions and the formation of hydrogen bonds between RES and PG. Caco-2 monolayer permeation tests showed that, at low RES loading concentrations (15 and 30 μg/mL), PG-RES solid dispersions achieved greater permeation of RES (0.60 and 1.32 μg/well, respectively) than RES alone (0.32 and 0.90 μg/well, respectively). At an RES loading of 150 μg/mL, PG-RES solid dispersion realized RES permeation of 5.89 μg/well, suggesting the potential of PG in enhancing the bioavailability of RES.

摘要

本研究考察了植物糖原（PG）提高白藜芦醇（RES）水溶性和生物利用度的能力。通过共溶剂混合和喷雾干燥将RES和PG制成PG-RES固体分散体。PG-RES固体分散体中RES的溶出量在PG:RES比例为50:1时达到289.6μg/mL，而单独的RES为45.6μg/mL。X射线粉末衍射和傅里叶变换红外光谱测试表明，PG-RES固体分散体中RES的结晶度显著降低，且RES与PG之间形成了氢键。Caco-2单层渗透试验表明，在低RES负载浓度（15和30μg/mL）下，PG-RES固体分散体中RES的渗透量（分别为0.60和1.32μg/孔）高于单独的RES（分别为0.32和0.90μg/孔）。在RES负载量为150μg/mL时，PG-RES固体分散体中RES的渗透量为5.89μg/孔，表明PG在提高RES生物利用度方面具有潜力。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1580/10063939/f03c565e9591/11483_2023_9785_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1580/10063939/82d273e5251b/11483_2023_9785_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1580/10063939/892f6adc4c1f/11483_2023_9785_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1580/10063939/ded67c918fc3/11483_2023_9785_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1580/10063939/47bd9d6f9dd3/11483_2023_9785_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1580/10063939/d39ceccb6f59/11483_2023_9785_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1580/10063939/f03c565e9591/11483_2023_9785_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1580/10063939/82d273e5251b/11483_2023_9785_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1580/10063939/892f6adc4c1f/11483_2023_9785_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1580/10063939/ded67c918fc3/11483_2023_9785_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1580/10063939/47bd9d6f9dd3/11483_2023_9785_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1580/10063939/d39ceccb6f59/11483_2023_9785_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1580/10063939/f03c565e9591/11483_2023_9785_Fig6_HTML.jpg

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