Suppr超能文献

新型冠状病毒肺炎相关毛霉菌病

COVID-19 Associated Mucormycosis.

作者信息

Tazeem Sana, Nagaraju A, Begum Hazeera, Tommi Joshi Anto, Sudarshan Reddy L, Vijay Kumar M

机构信息

Osmania Medical College, Hyderabad, India.

Department of ENT, Osmania Medical College, Hyderabad, India.

出版信息

Indian J Otolaryngol Head Neck Surg. 2023 Jun 10;75(4):1-9. doi: 10.1007/s12070-023-03676-7.

Abstract

Mucormycosis is a life-threatening opportunistic fungal infection seen in immunocompromised states. Rising incidence of mucormycosis among Coronavirus Disease-2019 infected individuals is an increasing concern in India. The disease which was endemic has blown out to become an epidemic. The purpose of this research is to study the epidemiology, management and outcome of Coronavirus Disease-2019 Associated Mucormycosis (CAM) cases. Additionally, the role of diabetes and steroids in the causation of CAM was determined. A hospital-based observational study was conducted at a tertiary care centre involving cases with rhino-orbital mucormycosis with recent history of COVID-19 infection. Out of 205,166(81%) cases had Diabetes Mellitus as a comorbid condition. Among them, 75(36.6%) cases were diagnosed with diabetes during COVID-19 treatment. 161/205(78.5%) cases received corticosteroids during COVID-19 treatment. Corticosteroids were notindicated in 43(26.7%) cases. 177/205(85.4%) cases were alive at the end of 12 weeks. 8 out of 10 deaths were seen in cases having diabetes. As the incidence of mucormycosis is increasing, better awareness among general population about the disease, early diagnosis and multidisciplinary approach is required to improve prognosis.

摘要

毛霉病是一种在免疫功能低下状态下出现的危及生命的机会性真菌感染。在2019年冠状病毒病感染个体中,毛霉病发病率不断上升,这在印度日益受到关注。这种原本为地方性的疾病已演变成一种流行病。本研究的目的是探讨2019年冠状病毒病相关毛霉病(CAM)病例的流行病学、治疗及转归。此外,还确定了糖尿病和类固醇在CAM病因中的作用。在一家三级护理中心开展了一项基于医院的观察性研究,纳入近期有新冠病毒感染史的鼻眶毛霉病病例。在205例患者中,166例(81%)有糖尿病合并症。其中,75例(36.6%)在新冠病毒治疗期间被诊断出患有糖尿病。205例中有161例(78.5%)在新冠病毒治疗期间接受了皮质类固醇治疗。43例(26.7%)病例未使用皮质类固醇。12周结束时,205例中有177例(85.4%)存活。10例死亡病例中有8例患有糖尿病。由于毛霉病发病率不断上升,需要提高普通人群对该疾病的认识、进行早期诊断并采取多学科方法以改善预后。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5609/10646093/c3d0f4d87e53/12070_2023_3676_Fig1_HTML.jpg

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验