使用高油酸向日葵油制备的纳米乳液提高萝卜籽提取物中萝卜硫素的稳定性和生物利用度。
Enhancing stability and bioavailability of sulforaphene in radish seed extracts using nanoemulsion made with high oleic sunflower oil.
作者信息
Lee Tae Kyung, Hur Gihyun, Choi Jeongyoon, Ban Choongjin, Kim Jong-Yea, Yang Hee, Park Jung Han Yoon, Lee Ki Won, Kim Jong Hun
机构信息
Biomodulation Major, Department of Agricultural Biotechnology, Seoul National University, Seoul, 08826 Republic of Korea.
Department of Next Generation Applied Sciences, Graduate School, Sungshin Women's University, Seoul, 01133 Republic of Korea.
出版信息
Food Sci Biotechnol. 2023 Apr 4;32(9):1269-1279. doi: 10.1007/s10068-023-01304-2. eCollection 2023 Aug.
UNLABELLED
The effect of nanoemulsions on the stability and bioavailability of sulforaphene (SFEN) in radish seed extract (RSE) was investigated. Four types of oil were used as lipid ingredients of the nanoemulsions: soybean, high oleic acid sunflower, coconut, and hydrogenated palm oils. SFEN in RSE nanoemulsions showed greater stability to temperature, acid, and alkaline conditions than SFEN in RSE suspended in water (RSE-S). Particularly under alkaline conditions, the half-life of SFEN in the nanoemulsion with high oleic sunflower oil (RSE-HOSO) was 8 times longer than that of RSE-S. Furthermore, in the pharmacokinetics study, it was observed that AUC increased and oral clearance (CL/F) decreased significantly in rats orally administered RSE-HOSO compared with RSE-S ( 0.05). This study indicates that the type of oil used in nanoemulsions affects the stability and bioavailability of SFEN in RSE. These results may provide a guideline for the development of functional foods containing RSE.
SUPPLEMENTARY INFORMATION
The online version contains supplementary material available at 10.1007/s10068-023-01304-2.
未标注
研究了纳米乳剂对萝卜籽提取物（RSE）中萝卜硫素（SFEN）稳定性和生物利用度的影响。使用了四种油作为纳米乳剂的脂质成分：大豆油、高油酸葵花籽油、椰子油和氢化棕榈油。与悬浮于水中的RSE（RSE-S）中的SFEN相比，RSE纳米乳剂中的SFEN在温度、酸性和碱性条件下表现出更高的稳定性。特别是在碱性条件下，高油酸葵花籽油纳米乳剂（RSE-HOSO）中SFEN的半衰期比RSE-S中的长8倍。此外，在药代动力学研究中，观察到与RSE-S相比，口服给予RSE-HOSO的大鼠的AUC显著增加，口服清除率（CL/F）显著降低（P<0.05）。本研究表明，纳米乳剂中使用的油的类型会影响RSE中SFEN的稳定性和生物利用度。这些结果可能为含RSE的功能性食品的开发提供指导。
补充信息
在线版本包含可在10.1007/s10068-023-01304-2获取的补充材料。
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