通过双模态光声和超声成像可视化早期睾丸扭转
Visualizing the early-stage testicular torsion by dual-modal photoacoustic and ultrasound imaging.
作者信息
Zhou Mengyu, Zhang Luting, Zeng Jianwen, Lan Yintao, He Fengbing, Gao Weijian, Li Jinghang, Wang Qian, Guo Weisheng, Yuan Zhen, Zhang Jian
机构信息
School of Biomedical Engineering, Guangzhou Medical University, Guangzhou, Guangdong, China.
Guangdong Engine Research Center of Urinary Continence and Reproductive Medicine, The Sixth Affiliated Hospital of Guangzhou Medical University, Qingyuan, Guangdong, China.
出版信息
Photoacoustics. 2023 Jun 9;31:100523. doi: 10.1016/j.pacs.2023.100523. eCollection 2023 Jun.
Delayed treatment of testicular torsion (TT) can lead to permanent loss of reproductive capacity. Photoacoustic imaging (PAI) and ultrasound imaging (USI) was tested for detecting TT at early stage in mice based on PAI-obtained oxygen saturation (sO), and USI-collected color pixel density (CPD), peak systolic velocity (PSV) and resistance index (RI). For complete TT, both CPD (9.08 % ± 3.084 to almost zero) and sO data (70.09 % ± 1.656-59.84 % ± 1.427) showed an significant change 2 h post-torsion. For incomplete TT, sO data exhibited a strong time relationship (Mean values: 6 h, 64.83 % ± 1.898; 12 h, 60.67 % ± 3.555; 24 h, 57.85 % ± 3.575; P < 0.05). However, USI-collected CPD, PSV or IR data from the same TT models showed no significant difference. This study indicated that USI and PAI could identify complete TT. Meanwhile, PAI has shown great potential in the diagnosis of incomplete TT within 24 h based on time-related sO map.
睾丸扭转（TT）的延迟治疗可导致生殖能力的永久性丧失。基于光声成像（PAI）获得的氧饱和度（sO）以及超声成像（USI）采集的彩色像素密度（CPD）、收缩期峰值流速（PSV）和阻力指数（RI），对小鼠早期检测TT的光声成像（PAI）和超声成像（USI）进行了测试。对于完全性TT，扭转后2小时CPD数据（9.08%±3.084至几乎为零）和sO数据（70.09%±1.656 - 59.84%±1.427）均显示出显著变化。对于不完全性TT，sO数据呈现出很强的时间相关性（平均值：6小时，64.83%±1.898；12小时，60.67%±3.555；24小时，57.85%±3.575；P<0.05）。然而，来自相同TT模型的USI采集的CPD、PSV或IR数据未显示出显著差异。本研究表明，USI和PAI可识别完全性TT。同时，基于与时间相关的sO图，PAI在24小时内诊断不完全性TT方面显示出巨大潜力。
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