德尔塔和奥密克戎变体的不同突变：新冠疫情各波次中病毒不同属性背后的关键因素。

Divergent mutations of Delta and Omicron variants: key players behind differential viral attributes across the COVID-19 waves.

作者信息

Panja Amrita, Roy Jayita, Mazumder Anup, Choudhury Sujata Maiti

机构信息

Midnapore, West Bengal 721102 India Biochemistry, Molecular Endocrinology, and Reproductive Physiology Laboratory, Department of Human Physiology, Vidyasagar University, Paschim Medinipore.

Nadia, Kalyani, West Bengal 741251 India National Institute of Biomedical Genomics (NIBMG).

出版信息

Virusdisease. 2023 May 10;34(2):1-14. doi: 10.1007/s13337-023-00823-0.

UNLABELLED

The third SARS-CoV-2 pandemic wave causing Omicron variant has comparatively higher replication rate and transmissibility than the second wave-causing Delta variant. The exact mechanism behind the differential properties of Delta and Omicron in respect to infectivity and virulence is not properly understood yet. This study reports the analysis of different mutations within the receptor binding domain (RBD) of spike glycoprotein and non-structural protein (nsp) of Delta and Omicron strains. We have used computational studies to evaluate the properties of Delta and Omicron variants in this work. Q498R, Q493R and S375F mutations of RBD showed better docking scores for Omicron compared to Delta variant of SARS-CoV-2, whereas nsp3_L1266I with PARP15 (7OUX), nsp3_L1266I with PARP15 (7OUX), and nsp6_G107 with ISG15 (1Z2M) showed significantly higher docking score. The findings of the present study might be helpful to reveal the probable cause of relatively milder form of COVID-19 disease manifested by Omicron in comparison to Delta variant of SARS-CoV-2 virus.

SUPPLEMENTARY INFORMATION

The online version contains supplementary material available at 10.1007/s13337-023-00823-0.

未标注

导致奥密克戎变种的第三次新冠疫情浪潮的复制率和传播性比导致德尔塔变种的第二次浪潮相对更高。德尔塔和奥密克戎在传染性和毒力方面不同特性背后的确切机制尚未得到充分理解。本研究报告了对德尔塔和奥密克戎毒株刺突糖蛋白受体结合域（RBD）和非结构蛋白（nsp）内不同突变的分析。在这项工作中，我们使用了计算研究来评估德尔塔和奥密克戎变种的特性。与新冠病毒德尔塔变种相比，RBD的Q498R、Q493R和S375F突变在奥密克戎毒株中显示出更好的对接分数，而nsp3_L1266I与PARP15（7OUX）、nsp3_L1266I与PARP15（7OUX）以及nsp6_G107与ISG15（1Z2M）显示出显著更高的对接分数。本研究结果可能有助于揭示与新冠病毒德尔塔变种相比，奥密克戎毒株导致的新冠疾病症状相对较轻的可能原因。