Institute of Pharmacology, Hannover Medical School, Carl-Neuberg-Strasse 1, D-30625 Hannover, Germany.
Institute of Microbiology of the Bundeswehr, Neuherbergstrasse 11, D-80937 Munich, Germany.
Trends Biochem Sci. 2023 Oct;48(10):835-838. doi: 10.1016/j.tibs.2023.05.013. Epub 2023 Jun 24.
In bacteria, cCMP and cUMP have a key role in defense against infection with bacterial viruses. Bacteriophages encode phosphodiesterases (PDEs; 'nucleases'; Apyc1), which cleave cCMP/cUMP, counteracting this defense. We propose that PDEs are of broader biological relevance, including cCMP/cUMP-cleaving PDEs of eukaryotic viruses, which may constitute new drug targets.
在细菌中，cCMP 和 cUMP 在防御细菌病毒感染方面起着关键作用。噬菌体编码磷酸二酯酶（PDEs；核酸酶；Apyc1），可切割 cCMP/cUMP，从而破坏这种防御。我们提出 PDEs 具有更广泛的生物学意义，包括真核病毒的 cCMP/cUMP 裂解 PDEs，它们可能成为新的药物靶点。
